LOINC
Version 2.70

LP16048-8CocaineActive

Descriptions

LP16048-8   Cocaine
Cocaine is an alkaloid of Erythroxylon coca that is grown in the northern South American Andes, India, Africa and Java. It is used medicinally as a local anesthetic and vasoconstrictor in nasal surgery and to dilate pupils. Because cocaine is a powerful central nervous system stimulant it is among the most abused drugs. Cocaine abuse can lead to sudden death due to cardiotoxicity or the sequential development of hyperthermia, agitated delirium and respiratory arrest. Cocaine is metabolized in the liver to inactive benzoylecgonine (BZE). BZE is pharmacologically inactive and has a longer half-life than its parent drug cocaine. It is the substance most tested for when investigating suspected cocaine abuse. Cocaethylene (CE) is produced in the liver in the presence of ethanol and has been shown to have similar stimulatory effects as cocaine in animal studies.(Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, Seventh Edition) Cocaethylene is toxic to the myocardium. [PMID: 8761012] Source: Regenstrief LOINC

LP16048-8   Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. Source: National Library of Medicine, MeSH 2006

Basic Part Properties

Name
Cocaine
Type
Component
Created On
2000-05-04
Construct for LOINC Short Name
Cocaine

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP16048-8

Language Variants Get Info

zh-CNChinese (China)
可卡因
Synonyms: C17H21NO4;古柯碱;可卡因粉;快克;柯卡因;白粉;白面儿
nl-NLDutch (Netherlands)
cocaïne
et-EEEstonian (Estonia)
Kokaiin
fr-BEFrench (Belgium)
Cocaïne
fr-CAFrench (Canada)
Cocaïne
it-ITItalian (Italy)
Cocaina
ru-RURussian (Russian Federation)
Кокаин
es-ESSpanish (Spain)
Cocaína
Synonyms: Benzoato de ecgonina metil éster;Benzoilmetilecgonina;Coca;Crack;Nieve
tr-TRTurkish (Turkey)
Kokain
Synonyms: Benzoilmetilecgonina