LOINC
Version 2.73

LP16714-5HistoneActive

Description

LP16714-5   Histone
Histones are small nuclear proteins that together with dsDNA, represent a nucleosome, the structural unit of chromatin. Anti-histone antibodies are associated with various autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren's syndrome, systemic sclerosis, infectious diseases (including HIV), and some neurological disorders such as Alzheimer's disease and dementia. Nearly all patients with drug-induced SLE have anti-histone antibodies, but they are also present in patients with idiopathic forms of the disease. One study showed a correlation between SLE with positive anti-dsDNA, anti-nucleosome and anti-histone antibodies and renal disease, including proliferative glomerulonephritis. [PMID:24649358] Source: Regenstrief LOINC, PMID: 24649358

Basic Part Properties

Name
Histone
Type
Component
Created On
2000-05-04
Construct for LOINC Short Name
Histone

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP16714-5

Language Variants Get Info

zh-CNChinese (China)
组蛋白
Synonyms: 组朊
nl-NLDutch (Netherlands)
histon
et-EEEstonian (Estonia)
Histoon
fr-BEFrench (Belgium)
Histone
fr-CAFrench (Canada)
Histone
it-ITItalian (Italy)
Istone
ru-RURussian (Russian Federation)
Гистон
es-ESSpanish (Spain)
Histona
tr-TRTurkish (Turkey)
Histon