Version 2.73

LP16719-4Jo-1 extractable nuclearActive


LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books:NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. [PMID:23573256] Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. [PMID:17392287] Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Basic Part Properties

Jo-1 extractable nuclear
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Language Variants Get Info

zh-CNChinese (China)
Jo-1 可提取性核
Synonyms: ENA Jo1;ENA Jo-1;Jo-1 可提取性核 Ag;Jo-1 可提取性核抗原;可提取性核 Ag Jo1;可提取性核 Ag Jo-1;可提取性核抗原 Jo1;可提取性核抗原 Jo-1;组氨酰-tRNA 合成酶;组氨酰基-tRNA 合成酶
nl-NLDutch (Netherlands)
jo-1 extraheerbaar nucleair
fr-BEFrench (Belgium)
Jo-1 nucléaire soluble
fr-CAFrench (Canada)
Jo-1 nucléaire soluble
it-ITItalian (Italy)
Jo-1, nucleare estraibile
Synonyms: Jo1
ru-RURussian (Russian Federation)
Jo-1 экстрагируемый ядерный
Synonyms: Jo1
es-ESSpanish (Spain)
Synonyms: Histidil-tRNA sintetasa
tr-TRTurkish (Turkey)
Jo-1 öztlenebilir çekirdek