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LP16728-5Neutrophil cytoplasmicActive


LP16728-5   Neutrophil cytoplasmic
Neutrophil cytoplasmic antibodies are autoantibodies that bind to the granulocytes of neutrophils. These antibodies were first identified in patients with Wegener's granulomatosis (WG) who also had systemic vasculitis and necrotizing crescentic glomerulonephritis. When viewed under a fluorescent microscope, a typical cytoplasmic fluorescent pattern is visible. These ANCA are called cytoplasmic ANCA (c-ANCA) and the antigen they target is proteinase 3 (PR3) which is part of the azurophilic granules of neutrophils. The perinuclear ANCA (p-ANCA) targets the antigen myeloperoxidase (MPO) and is associated with idiopathic forms of systemic vasculitis and glomerulonephritis. A third ANCA antibody is the atypical ANCA (a-ANCA). The presence of a-ANCA has been found in patients with inflammatory bowel diseases including ulcerative colitis (UC) and Crohn's disease (CD), autoimmune-mediated liver diseases, rheumatoid arthritis RA, and systemic lupus erythematosus (SLE).[PMID:27366026] Source: Regenstrief LOINC

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Neutrophil cytoplasmic
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zh-CNChinese (China)
Synonyms: ANCA;中性白细胞细胞浆;中性白细胞胞浆;中性粒细胞细胞浆;中性粒细胞胞浆;嗜中性白细胞细胞浆;嗜中性白细胞胞浆;嗜中性粒细胞胞浆;粒细胞核抗体;粒细胞细胞核抗体
nl-NLDutch (Netherlands)
neutrofiel cytoplasmatisch
fr-BEFrench (Belgium)
Neutrophile cytoplasmique
fr-CAFrench (Canada)
Neutrophile cytoplasmique
it-ITItalian (Italy)
Neutrofilo citoplasmico
ru-RURussian (Russian Federation)
Нейтрофилов цитоплазматический
es-ESSpanish (Spain)
Citoplasma de neutrófilo
tr-TRTurkish (Turkey)
Nötrofil sitoplazmik