LOINC
Version 2.72

LP16758-2SCL-70 extractable nuclearActive

Description

LP16758-2   SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. [PMID:11229469] Source: Regenstrief LOINC, PMID: 11229469

Basic Part Properties

Name
SCL-70 extractable nuclear
Type
Component
Created On
2000-05-04
Construct for LOINC Short Name
ENA Scl70

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP16758-2

Language Variants Get Info

zh-CNChinese (China)
SCL-70 可提取性核
Synonyms: ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体
nl-NLDutch (Netherlands)
SCL-70 extraheerbare nucleaire
fr-BEFrench (Belgium)
SCL-70 nucléaire soluble
fr-CAFrench (Canada)
SCL-70 nucléaire soluble
it-ITItalian (Italy)
Nucleare estraibile SCL-70
ru-RURussian (Russian Federation)
SCL-70 экстрагируемый ядерный
es-ESSpanish (Spain)
Antígeno nuclear extraíble SCL-70
Synonyms: Anticuerpos para Esclerodermia
tr-TRTurkish (Turkey)
SCL-70 özütlenebilir nükleer