LP16758-2SCL-70 extractable nuclearActive
Description
LP16758-2 SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. [PMID:11229469]
Source: Regenstrief LOINC, PMID: 11229469
Basic Part Properties
- Name
- SCL-70 extractable nuclear
- Type
- Component
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- ENA Scl70
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP16758-2
Language Variants Get Info
- zh-CNChinese (China)
- SCL-70 可提取性核
Synonyms: ENA SCL-70;SCL-70 可提取性核 Ag; SCL-70 可提取性核抗原; 可提取性核抗原 SCL-70; 皮硬化症 Ab; 皮硬化症抗体; 硬皮病 Ab; 硬皮病抗体; 硬皮症 Ab; 硬皮症抗体 - nl-NLDutch (Netherlands)
- SCL-70 extraheerbare nucleaire
- fr-BEFrench (Belgium)
- SCL-70 nucléaire soluble
- fr-CAFrench (Canada)
- SCL-70 nucléaire soluble
- it-ITItalian (Italy)
- Nucleare estraibile SCL-70
- ru-RURussian (Russian Federation)
- SCL-70 экстрагируемый ядерный
- es-ESSpanish (Spain)
- Antígeno nuclear extraíble SCL-70
Synonyms: Anticuerpos para Esclerodermia - tr-TRTurkish (Turkey)
- SCL-70 özütlenebilir nükleer
LOINC Copyright
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