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LP17260-8Purkinje cellsActive


LP17260-8   Purkinje cells
Purkinje cells (or Purkinje neurons) are a class of GABAergic neuron located in the cerebellar cortex.

These cells are some of the largest neurons in the human brain, with an intricately elaborate dendritic arbor, characterized by a large number of dendritic spines. Purkinje cells are found within the Purkinje layer in the cerebellum. Purkinje cells are aligned like dominos stacked one in front of the other. Their large dendritic arbors form nearly two dimensional layers through which parallel fibers from the deeper-layer granule cells pass. These parallel fibers make relatively weaker excitatory (glutamatergic) synapses to spines in the Purkinje cell dendrite, whereas climbing fibers originating from the inferior olivary nucleus in the medulla provide very powerful excitatory input to the proximal dendrites and cell soma.

In humans, Purkinje cells are affected in a variety of diseases ranging from toxic exposure (alcohol, lithium), to autoimmune diseases and to genetic mutations (spinocerebellar ataxias, Unverricht-Lundborg disease, autism) and neurodegenerative diseases that are not thought to have a known genetic basis (cerebellar type of multiple system atrophy, sporadic ataxias). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Purkinje cells (Wikipedia)

LP17260-8   Purkinje cells
The output neurons of the cerebellar cortex. Source: National Library of Medicine, MeSH 2006

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Purkinje cells
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Purkinje Cells

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Language Variants Get Info

zh-CNChinese (China)
Synonyms: Purkinje 细胞;朴金耶细胞;浦金埃细胞
nl-NLDutch (Netherlands)
et-EEEstonian (Estonia)
Purkinje rakkude vastased
fr-BEFrench (Belgium)
Cellules de Purkinje
fr-CAFrench (Canada)
Cellules de Purkinje
it-ITItalian (Italy)
Cellule di Purkinje
ru-RURussian (Russian Federation)
Пуркинье клетки
es-ESSpanish (Spain)
Células de Purkinje
tr-TRTurkish (Turkey)
Purkinje hücreleri