LOINC
Version 2.73

LP172674-6Phospholipase A2 receptor IgGActive

Description

LP172674-6   Phospholipase A2 receptor Ab.IgG
The M-type phospholipase A2 receptor (PLA2R) stimulates the production of phospholipase A2 receptor autoantibodies. The PLA2R antibodies are a sensitive biomarker for idiopathic membranous nephropathy (MN). Over 80% of patients with MN are positive for PLA2R antibodies. MN is a syndrome where immune complexes deposit on the basement membrane and along with complement fixation alter the filtration barrier leading to proteinuria. The target antigens reside on the podocytes and is where the disease process begins. PLA2R antibodies are useful to diagnose and monitor treatment of MN. [PMCID:PMC3103733] Source: Regenstrief LOINC

Basic Part Properties

Name
Phospholipase A2 receptor Ab.IgG
Type
Component
Created On
2013-02-18

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