LOINC
Version 2.67

LP173627-3PDGFR-alphaActive

Descriptions

LP173627-3   PDGFR-alpha
Platelet-derived growth factor receptors (PDGFRs) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGFR-- alpha and beta -- each encoded by a different gene. Depending on which growth factor is bound, PDGFR homo- or heterodimerizes. Like many other growth factors that have been linked to disease, PDGF and its receptors have provided a market for receptor antagonists to treat disease. Such antagonists include (but are not limited to) specific antibodies that target the molecule of interest, which act only in a neutralizing manner. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, PDFGR (Wikipedia)

LP173627-3   PDGFR-alpha
Platelet-derived growth factor receptors (PDGFRs) exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and -beta receptors. PDGF-alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons. Source: LOINC partner 1

Basic Part Properties

Name
PDGFR-alpha
Type
Component
Created On
2013-08-01
Construct for LOINC Short Name
PDGFR-alpha

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP173627-3

Language Variants Get Info

zh-CNChinese (CHINA)
PDGFR-alpha
Synonyms: PDGFR-α;PDGFRA;血小板衍生生长因子受体;血小板源生长因子受体;Platelet-derived growth factor receptor;PDGFRr;PDGF 受体
nl-NLDutch (NETHERLANDS)
PDGFR-alfa
it-ITItalian (ITALY)
PDGFR alfa
ru-RURussian (RUSSIAN FEDERATION)
PDGFR-альфа
Synonyms: Фактор роста тромбоцитов-альфа
es-ESSpanish (SPAIN)
Receptor del factor de crecimiento derivado de plaquetas alfa
tr-TRTurkish (TURKEY)
PDGFR-alpha