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Major histocompatibility complex class I chain-related antigen A (MICA) proteins are like HLA class I gene products. MICA has a role as a ligand for activation of receptor NKG2D. Like the HLA system, MICA molecules can elicit antibody responses during pregnancy, blood product transfusion, or organ transplant rejection. A significant percentage of exposed individuals will produce anti-MICA antibodies. Presence or absence of MICA antibodies may assist clinicians in determining the survival of organ transplant patients. Source: Regenstrief LOINC

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