LP17880-3

Hydroxybupropion

Active

Descriptions

Hyroxybupropion is a metabolite of bupropion. Source: Regenstrief LOINC

Hydroxybupropion, also known as 6-hydroxybupropion and BW 306U, is the major active metabolite of the antidepressant and smoking cessation drug bupropion. It is formed from bupropion by the enzyme CYP2B6. With oral bupropion treatment, hydroxybupropion is present in plasma at area under the curve concentrations that are as many as 16 times greater than those of bupropion itself, demonstrating extensive first-pass metabolism of bupropion into hydroxybupropion in humans. As such, hydroxybupropion is likely to play a very important role in the effects of oral bupropion, which could be accurately thought of as functioning in large part as a prodrug to hydroxybupropion. [Wikipedia: Hydroxybupropion] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Hydroxybupropion

Basic Part Properties

Part Display Name

Hydroxybupropion

Part Type

Component (Describes the core component or analyte measured)

Created On

2000-05-04

Construct for LOINC Short Name

OH-bupropion

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