Version 2.74


Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. [PMID: 7532143] GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years.[PMID: 11114103] GAD67 is important to the maturation of perisomatic innervation.( GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located.[PMID: 22412264] Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases.[PMID: 22405456] Source: Regenstrief LOINC

Basic Part Properties

Glutamate decarboxylase 65
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name

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Language Variants

Tag Language Translation
zh-CN Chinese (China) 谷氨酸脱羧酶-65
Synonyms: GAD65;GAD-65;谷氨酸脱羧酶 65;谷氨酸脱羧酶 65(Glutamate Decarboxylase 65,GAD65,Glutamic acid decarboxylase-65,GAD-65)
fr-CA French (Canada) Glutamate décarboxylase 65
et-EE Estonian (Estonia) Glutamaadi dekarboksülaasi 65 vastased
es-ES Spanish (Spain) Glutamato decarboxilasa 65
it-IT Italian (Italy) Glutammato decarbossilasi 65
Synonyms: GAD65
tr-TR Turkish (Turkey) Glutamat dekarboksilaz 65
ru-RU Russian (Russian Federation) Глутаматдекарбоксилаза 65
nl-NL Dutch (Netherlands) glutamaatdecarboxylase 65
fr-BE French (Belgium) Glutamate décarboxylase 65