LOINC
Version 2.73

LP220359-6ZoActive

Description

LP220359-6   Zo
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books:NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. [PMID:23573256] Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. [PMID:17392287] Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Basic Part Properties

Name
Zo
Type
Component
Created On
2016-07-01
Construct for LOINC Short Name
Zo

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Language Variants Get Info

zh-CNChinese (China)
Zo
Synonyms: phenylalanyl;苯基丙氨酰;苯丙氨酰基;Zo;Aminoacyl-tRNA synthetases;ARS;氨基酰-tRNA合成酶;苯基丙氨酰-tRNA 合成酶;苯丙氨酰基-tRNA 合成酶;
it-ITItalian (Italy)
Zo
es-ESSpanish (Spain)
Zo