Version 2.73

LP232481-4Neutrophil membrane IgMActive


LP232481-4   Neutrophil membrane Ab.IgM
Antineutrophil antibodies are antibodies that bind to antigens on the surface of neutrophils. The IgG Fc receptor on the neutrophil membrane surface is the primary target for antineutrophil antibodies. It was first recognized that these antibodies were a cause of autoimmune neutropenia (AIN) in 1975. Neutropenia is separated into three categories according to the risk of infection and based on the concentration of circulating neutrophils: mild neutropenia (1000-1500 cells/uL) moderate neutropenia (500-1000 cells/uL) and severe (less than 500 cells/uL). In some AIN the neutrophil numbers are normal but some functions are compromised including their ability to influence adhesion, aggregation, chemotaxis, phagocytosis and metabolic activation. AIN has two subcategories including primary AIN and secondary AIN. In primary IAN there is no association with another pathology. Primary IAN is most common in neonates and results in moderate to severe neutropenia, rarely leads to infection and is self-limiting. Secondary IAN usually occurs following a systemic autoimmune or haemitological disease including infectious diseases, solid or haematological neoplasms, neurological diseases, bone marrow or stem cell trnasplants, kidney transplants and the use of some drugs. In light of the difficulty in detecting autoimmune antineutrophil antibodies, it is recommended that both immunofluorescent and agglutination tests be performed.[PMID:16207350] Source: Regenstrief LOINC

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Neutrophil membrane Ab.IgM
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Neutrophil membrane Ab.IgM

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