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LP262495-7Escherichia coli enterotoxigenic sta geneActive


LP262495-7   Escherichia coli enterotoxigenic sta gene
Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt:Q70Q79]; [UniProt:Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea.[PMID:8528070] The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea.[PMID:23716609] Source: Regenstrief LOINC

Basic Part Properties

Escherichia coli enterotoxigenic sta gene
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Construct for LOINC Short Name
ETEC sta gene

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Language Variants Get Info

zh-CNChinese (China)
大肠埃希菌肠产毒素型 sta 基因
Synonyms: 大肠埃希菌(E coli、大肠埃希氏杆菌、大肠埃希氏菌、大肠杆菌)肠产毒素型(肠产毒素性、产肠毒素性、产肠毒素型、肠毒性、肠毒型、产肠毒性、产肠毒型) sta 基因
nl-NLDutch (Netherlands)
Escherichia coli enterotoxine-gen hittegevoelig toxine
it-ITItalian (Italy)
Escherichia coli enterotossigeni gene sta
es-ESSpanish (Spain)
Gen sta Escherichia coli enterotoxigenico