LP262496-5
Escherichia coli enterotoxigenic heat-labile toxin DNA
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Description
Enterotoxigenic Escherichia coli (ETEC) produces a heat-labile (LT) and a heat-stable (ST) enterotoxin, both of which cause severe diarrhea in both humans and animals. ST is an extracellular toxin which is comprised of a methanol-soluble (STa) toxin and a methanol-insoluble (STb) toxin. The sta gene encodes the STa toxin and the stb gene encodes the STb toxin. [UniProt: Q70Q79]; [UniProt: Q70Q73] STa combines to its enterocyte receptor, guanylate cyclase, which causes intestinal secretion and diarrhea. PMID: 8528070 The STb enterocyte receptor is the protein sulfatide. After STb binds to sulfatide, it is engulfed by the enterocyte. It then activates the pertussis toxin-sensitive G protein which opens the ligand-gated calcium ion channel, allowing an influx of calcium ions. A subsequent secretion of chloride ions, stimulation of arachidonic acid release, and production of prostaglandin E2 and 5-dyroxytryptamine leads to an efflux of water, bicarbonate ions, sodium ions, and chloride ions into the intestinal space, all of which leads to watery diarrhea. PMID: 23716609 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Escherichia coli enterotoxigenic heat-labile toxin DNA
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2017-07-18
- Construct for LOINC Short Name
- ETEC heat-lab tox DNA
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