LOINC
Version 2.73

LP268267-4MOG Ab.IgG1Active

Description

LP268267-4   Myelin oligodendrocyte glycoprotein Ab.IgG1
Myelin oligodendrocyte glycoprotein (MOG) is a protein made up of two polypeptides with molecular masses of 26 and 28 kilodaltons, respectively. MOG is located on the surface of myelin and oligodendrocyte cytoplasmic membranes and binds to the monoclonal antibody 8-18C5. [PMID:1373175] MOG is a probable autoantigen target associated with multiple sclerosis (MS) and other demyelinating diseases (DD) of the central nervous system. [PMID:1373175] That being said, there is variation in the level of MOG antibody found in patients with MS and DD with inconsistencies between MOG antibody measurements using western blot and ELISA test methods, making it a questionable biomarker for DD. [PMID:17294606] MOG IgG1 is the most prevalent isotype of IgG in patients with DD.[PMID:29063242] Source: Regenstrief LOINC

Basic Part Properties

Name
Myelin oligodendrocyte glycoprotein Ab.IgG1
Type
Component
Created On
2018-08-03
Construct for LOINC Short Name
MOG Ab.IgG1

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https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP268267-4