LP28754-7
Ganglioside GQ1b
Active
Description
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID: 21214559]
Source: Regenstrief LOINC, PMID: 2121455
Basic Part Properties
- Name
- Ganglioside GQ1b
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2002-03-07
- Construct for LOINC Short Name
- GQ1b Gangl
LOINC Terminology Service (API) using HL7® FHIR®
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP28754-7
Language Variants
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 神经节苷脂 GQ1b Synonyms: |
| fr-CA | French (Canada) | Ganglioside GQ1b |
| et-EE | Estonian (Estonia) | Gangliosiid GQ1b |
| es-ES | Spanish (Spain) | Gangliósido GQ1b |
| it-IT | Italian (Italy) | Ganglioside GQ1b |
| tr-TR | Turkish (Turkey) | Gangliozid GQ1b |
| ru-RU | Russian (Russian Federation) | Ганглиозид GQ1b |
| nl-NL | Dutch (Netherlands) | ganglioside GQ1b |
| fr-BE | French (Belgium) | Ganglioside GQ1b |
LOINC Copyright
Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright