LOINC
Version 2.73

LP35078-2Abnormal Prion ProteinActive

Description

LP35078-2   Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

Basic Part Properties

Name
Prion protein.abnormal
Type
Component
Created On
2005-02-15
Construct for LOINC Short Name
Abn Prion Prot

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP35078-2

Language Variants Get Info

zh-CNChinese (China)
朊病毒蛋白.异常
Synonyms: BSE;Scrapie;亲染子蛋白.异常;异常亲染子蛋白;异常感染性蛋白质;异常朊病毒蛋白;异常蛋白感染素;感染性蛋白质.异常;牛海绵状脑病;牛海绵状脑病(Bovine spongiform encephalopathy,BSE);疯牛病;羊痒病;羊瘙痒病;羊瘙痒病(Scrapie);蛋白感染素.异常
nl-NLDutch (Netherlands)
prioneiwit.abnormaal
fr-BEFrench (Belgium)
Protéines prion.anormales
fr-CAFrench (Canada)
Protéines prion.anormales
it-ITItalian (Italy)
Proteina prionica.anormale
Synonyms: Proteina Prionica Anormale
ru-RURussian (Russian Federation)
Прионный протеин.аномальный
Synonyms: Прионный белок.аномальный
es-ESSpanish (Spain)
Proteína priónica anormal
Synonyms: BSE;Encefalitis espogiforme bovina;Scrapie
tr-TRTurkish (Turkey)
Prion protein.anormal
Synonyms: Encefalitis espogiforme bovina