LP36423-9Ganglioside GM1Active

Description

LP36423-9   Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID:21214559] Source: Regenstrief LOINC, PMID: 2121455

Basic Part Properties

Name

Ganglioside GM1

Type

Component

Created On

2005-12-14

Construct for LOINC Short Name

GM1 Gangl

LOINC FHIR^® API Example - CodeSystem Request Get Info

Language Variants Get Info

zh-CNChinese (China)

神经节苷脂 GM1
Synonyms: GM1;神经节糖苷 GM1

nl-NLDutch (Netherlands)

ganglioside GM1

et-EEEstonian (Estonia)

Gangliosiid GM1

fr-BEFrench (Belgium)

Ganglioside GM1

fr-CAFrench (Canada)

Ganglioside GM1

it-ITItalian (Italy)

Ganglioside GM1

ru-RURussian (Russian Federation)

Ганглиозид GM1

es-ESSpanish (Spain)

Gangliósido GM1

tr-TRTurkish (Turkey)

Gangliozid GM1

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