LP36423-9Ganglioside GM1Active
Description
LP36423-9 Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. [PMID:21214559]
Source: Regenstrief LOINC, PMID: 2121455
Basic Part Properties
- Name
- Ganglioside GM1
- Type
- Component
- Created On
- 2005-12-14
- Construct for LOINC Short Name
- GM1 Gangl
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP36423-9
Language Variants Get Info
- zh-CNChinese (China)
- 神经节苷脂 GM1
Synonyms: GM1;神经节糖苷 GM1 - nl-NLDutch (Netherlands)
- ganglioside GM1
- et-EEEstonian (Estonia)
- Gangliosiid GM1
- fr-BEFrench (Belgium)
- Ganglioside GM1
- fr-CAFrench (Canada)
- Ganglioside GM1
- it-ITItalian (Italy)
- Ganglioside GM1
- ru-RURussian (Russian Federation)
- Ганглиозид GM1
- es-ESSpanish (Spain)
- Gangliósido GM1
- tr-TRTurkish (Turkey)
- Gangliozid GM1
LOINC Copyright
Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright