LP37963-3 E Ag
Rh is the most complex of the blood groups systems, encompassing over 45 distinct antigens. The most clinical important antigen, D or Rho, was first described in 1940 and is present in over 85% of the population. Those individuals who lack the D antigen are considered to be Rh negative.
The Rh antigens are encoded by two highly homologous and closely linked genes on the short arm of chromosome 1. The RHD gene codes for the D antigen, or most of its components; RhCE gene codes the Cc and Ee antigens or their variants. The majority of the antigens within this system represent products of gene cross-over, point mutations or deletions within one or both genes.
The Rh antigens appear to be expressed only on red blood cell and they appear early during red cell development. Antibodies against the Rh antigens have caused severe and fatal transfusion reactions and hemolytic disease of the newborn. Rh antigens have been implicated in many diseases such as auto-immune hemolytic anemia, auto-Rh antibodies. Collect: One 4 mL green (sodium or lithium heparin) or serum separator tube. Also acceptable: lavender or pink (EDTA). Source: Serum, Cells and Rare Fluid Exchange, Rh
Basic Part Properties
- E Ag
- Created On
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- zh-CNChinese (CHINA)
- E 抗原
Synonyms: E 型抗原
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