LOINC
Version 2.68

LP40012-4Tissue transglutaminase AbActive

Descriptions

LP40012-4   Tissue transglutaminase Ab
Anti-transglutaminase antibodies (ATA) are antibodies found more frequently in certain autoimmune diseases. High levels (titers) of ATA are found in almost all instances of coeliac disease. Given the association of ATA with coeliac disease, and the prevalence of the latter it is estimated that ~1% of the population have potentially pathogenic levels of ATA. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP40012-4   Tissue transglutaminase Ab
Tissue transglutaminase (abbreviated as TG2 or tTG) is an enzyme (EC 2.3.2.13) of the transglutaminase family. Like other transglutaminases, it crosslinks proteins between an ε-amino group of a lysine residue and a γ-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation). It is an autoantigen in celiac disease, and is also known to play a role in apoptosis, cellular differentiation and matrix stabilisation. Serology for anti-tTG antibodies has superseded older serological tests (anti-endomysium, anti-gliadin and anti-reticulin) and has a strong sensitivity (99%) and specificity (>90%) for identifying coeliac disease. Modern anti-tTG assays rely on a human recombinant protein as an antigen. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Basic Part Properties

Name
Tissue transglutaminase Ab
Type
Component
Created On
2006-05-09

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP40012-4

Language Variants Get Info

zh-CNChinese (CHINA)
组织谷氨酰胺转移酶抗体
Synonyms: 组织谷氨酰胺转移酶 Ab;组织转谷氨酰胺酶 Ab;组织转谷氨酰胺酶抗体