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LP422925-0MLH1 gene methylation analysisActive


LP422925-0   MLH1 gene methylation analysis
The MLH1 gene (mutL homolog 1) [HGNC Gene ID:7127] is located on chromosome 3p21.3. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC), also known as Lynch syndrome. It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009] [NCBI Gene ID:4292] Source: National Center for Biotechnology Information (NCBI) Gene

LP422925-0   MLH1 gene methylation analysis
MLH1 gene methylation has been associated with many kinds of cancers with microsatellite instability Source: Regenstrief LOINC

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MLH1 gene methylation analysis
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MLH1 Methyl Anl

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