LOINC
Version 2.68

LP71704-8Human upstream binding factorActive

Description

LP71704-8   Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. [PMID: 25965800] Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. [PMID: 20175839] Source: Regenstrief LOINC, PMID: 20175839

Basic Part Properties

Name
Human upstream binding factor
Type
Component
Created On
2008-10-30
Construct for LOINC Short Name
hUBF

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP71704-8

Language Variants Get Info

zh-CNChinese (CHINA)
人上游结合因子
Synonyms: 人上遊結合因子;人类上游结合因子;hUBF;Human upstream binding factor
nl-NLDutch (NETHERLANDS)
Humaan upstream binding factor
et-EEEstonian (ESTONIA)
NOR-90
fr-BEFrench (BELGIUM)
Human upstream binding factor
fr-CAFrench (CANADA)
NOR-90
it-ITItalian (ITALY)
Fattore umano a monte legante
Synonyms: hUBF
ru-RURussian (RUSSIAN FEDERATION)
Человеческий upstream binding factor
es-ESSpanish (SPAIN)
factor de unión upstream humano
tr-TRTurkish (TURKEY)
Human upstream bağlayıcı factor