Version 2.73

LP71719-6U1 small nuclear ribonucleoprotein AActive


LP71719-6   U1 small nuclear ribonucleoprotein A
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. [PMID:24158973] In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. [PMID:20015915] Source: Regenstrief LOINC, PMID: 24158973

Basic Part Properties

U1 small nuclear ribonucleoprotein A
Created On
Construct for LOINC Short Name
U1 snRNP-A

LOINC FHIR® API Example - CodeSystem Request Get Info


Language Variants Get Info

zh-CNChinese (China)
U1 小细胞核核糖核蛋白 A
Synonyms: U1 RNP A;U1 snRNP A;U1 小细胞核核糖核蛋白 A;U1 small nuclear ribonucleoprotein A;U1RNP A
nl-NLDutch (Netherlands)
u1 small nucleair ribonucleoproteïne A
fr-BEFrench (Belgium)
Petite particule nucléaire ribonucléoprotéique U1 A
fr-CAFrench (Canada)
Petite particule nucléaire ribonucléoprotéique U1 A
it-ITItalian (Italy)
U1, piccola ribonucleoproteina nucleare A
Synonyms: Piccola ribonucleoproteina nucleare U1 A
ru-RURussian (Russian Federation)
U1 малый ядерный рибонуклеопротеин A
Synonyms: Piccola ribonucleoproteina nucleare U1 A
es-ESSpanish (Spain)
U1 ribonucleoproteína nuclear pequeña A
tr-TRTurkish (Turkey)
U1 kçk nükleer ribonükleoprotein A