Campesterol is a phytosterol, meaning it is a steroid derived from plants. As a food additive, phytosterols have cholesterol-lowering properties (reducing cholesterol absorption in intestines), and may act in cancer prevention. Phytosterols naturally occur in small amount in vegetable oils, especially soybean oil. One such phytosterol complex, isolated from vegetable oil, is cholestatin, composed of campesterol, stigmasterol, and brassicasterol, and is marketed as a dietary supplement. Sterols can reduce cholesterol in human subjects by up to 15%. The mechanism behind phytosterols and the lowering of cholesterol occurs as follows : the incorporation of cholesterol into micelles in the gastrointestinal tract is inhibited, decreasing the overall amount of cholesterol absorbed. This may in turn help to control body total cholesterol levels, as well as modify HDL, LDL and TAG levels. Many margarines, butters, breakfast cereals and spreads are now enriched with phytosterols and marketed towards people with high cholesterol and a wish to lower it.
[HMDB ID: HMDB02869] Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database
Phytosterols (e.g., β-sitosterol, campesterol, stigmasterol, and brassicasterol) are common components of plant foods,such as vegetable oils, seeds, and nuts. An average Western diet contains approx. 200-400 mg of phytosterols per day. Phytosterols are structurally similar to cholesterol and differ only in the number of carbons or double bonds in the side chain. Since serum and tissue phytosterols are derived from intestinal absorption, levels reflect dietary plant sterol intake and intestinal absorption. Markedly increased serum phytosterol concentrations (e.g., β-sitosterol > 50 mg/l) is seen in sitosterolemia, a rare autosomal recessive lipid disorder. These patients develop premature coronary heart disease. A study suggests that even slightly increased campesterol (3.8 ± 1.6 mg/l) and β-sitosterol (3.1 ± 1.1 mg/l) concentrations in serum may contribute to the risk of coronary heart disease.[PMID:15489546] Source: Regenstrief LOINC, PMID:15489546
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