Cellular Immunology Tests (Control serum)

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This topic contains 3 replies, has 2 voices, and was last updated by  kmercer 7 years, 3 months ago.

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  • #16253

    John Mok
    Participant

    Hi,
    I have a question for the group.
    My colleague is performing LOINC mapping for a clinical immunology lab at present.
    We find that there are dozens of cellular immunology tests related to patient serum mxied with control serum which most likely fail to map a LOINC code.
    For example: Natural Killer cell function – Lymphocytes Patient/Control, Target Effector 1:5 Patient/Control, Target Effector 1:10 Patient/Control, Target Effector 1:10 Patient/Control, Target Effector 1:20 Patient/Control, Target Effector 1:40 Patient/Control,Target Effector 1:80 Patient/Control,….
    Is there any suggestion?
    Say, propose a new LOINC to Regenstrief or create local LOINC for them
    Thanks in advance for your comment.

    Sincerely,
    John

    #16592

    kmercer
    Participant

    These may need to be local codes, but I can respond better if I could see and example report and product insert.

    #16593

    John Mok
    Participant

    Attached with a sample report:-

    NK CELL NUMBER & FUNCTION

    Specimen: Heparinised and EDTA blood

    PATIENT CONTROL NORMAL RANGE(For age)
    WBC 7060 /uL 4790 /uL 4500 – 8400
    Differential N(25) L(65) M(5) E(1) N(48) L(37) M(7) E(3)
    B(1) O(3) B(1) O(4)
    Lymphocytes 4582 H /uL 1782 /uL 1500 – 3200
    NK cells (CD3-CD16/56+) % 2.0 L % 12.2 % 11 – 24
    NK cells (CD3-CD16/56+) no. 93 L /uL 217 /uL 300 – 600

    MICROCYTOTOXICITY ASSAY
    Target cell : Effector cell NORMAL RANGE(Adult)
    1 : 5 0.7 L % 13.3 % 1 – 43
    1 : 10 4.6 % 21.0 % 2 – 68
    1 : 20 10.4 L % 36.6 % 15 – 78
    1 : 40 16.1 L % 48.9 % 23 – 77
    1 : 80 21.6 L % 53.9 % 27 – 80

    Comment: Low NK cytotoxicity partly due to low NK cell number. Taking this into
    consideration the NK cytotoxicity is considered impaired or low normal.

    #16594

    kmercer
    Participant

    We’d like to see a package insert. Can you provide one, or point to a URL for a package insert or reference information. Thanks.

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