Soluble Liver vs Cytokeratin – duplicates?

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This topic contains 3 replies, has 3 voices, and was last updated by  kmercer 9 years ago.

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  • #16161

    Pam Banning
    Participant

    Would like to hear opinions on if the terms Soluble Liver and Cytokerin antibodies are synonymous as a laboratory serology analyte? The following test catalogs indicate they are:

    http://www.specialtylabs.com/books/print_view.asp?id=270
    http://www.ucihs.uci.edu/som/pathology/Pathology%20Service%20Manual/SOLUBLE%20LIVER%20ANTIGEN%20ANTIBODY,%20IgG.htm
    http://www.floridapathology.com/testdescription.asp?ID=1027

    Thanks for your input!

    #16423

    Marilyn Stark
    Participant

    Hi Pam,
    We have these in our local RI dictionary as synonyms. There were created as such in 2003 and I’m copying the test description here in case that helps:
    Presence of autoantibodies against soluble liver antigens (SLA) which react with liver cytokeratins by EIA method reported as EU-Elisa Units. The presence of SLA antibodies has almost 100% specificity for autoimmune hepatitis, although only 12-30% have these antibodies. Thus, a negative SLA IgG test does not rule out autoimmune hepatitis. Auto Immune Hepatitis (AIH) Type 3 is characterized by the presence of autoantibodies against soluble liver antigens (SLA) which react with liver cytokeratins.

    Marilyn

    #16424

    Pam Banning
    Participant

    Hi Marilyn,

    Please check out the following LOINC codes:
    12734-0 Cytokeratin Ab:ACnc:Pt:Ser:Qn
    13925-3 Cytokeratin Ab:ACnc:Pt:Ser:Ord

    54026-0 Soluble Liver Ab:ACnc:Pt:Ser:Qn
    54029-4 Soluble Liver Ab:ACnc:Pt:Ser:Ord

    We believe these are duplicates. Thank you very much for your consideration!

    #16425

    kmercer
    Participant

    The requester of the 2 Soluble liver Ab codes felt that soluble liver antibodies were not quite the same as cytokeratin antibodies. I am trying to get supporting documentation from them.
    … Stay tuned 🙂

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