TPMT/NUDT15 Genotyping Mapping

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  • #466879
    HIU LAAM LAM
    Participant

    Dear Sir/Madam,

    I am writing to seek your advice on the mapping of TPMT/NUDT15 Genotyping test results.

    TPMT/NUDT15 Genotyping is a signtificant biomarker for thropurine toxcity. There are two types of reporting format in our laboratory system based on user perference.

    (1) All related information including genes, specimens, methods…etc are treated as a whole and mapped to 93193-1TPMT gene and NUDT15 gene targeted mutation analysis in Blood or Tissue by Molecular genetics method.

    (2) Reported in separated sections, e.g. each genotypic findings to specific LOINC concept. But for the clinical interpretation part, should I map to 93193-1TPMT gene and NUDT15 gene targeted mutation analysis in Blood or Tissue by Molecular genetics method like the above case OR I should create an HKLOINC TPMT gene and NUDT15 gene targeted mutation analysis in Blood or Tissue by Molecular genetics method Narrative?

    Thank you.

    Regards,

    Katherine

    #466880
    HIU LAAM LAM
    Participant

    Sorry that I am not able to post image in the forum.

    May I know where I can send the report image for your reference please? Thank you.

    #466885
    Tim Briscoe
    Keymaster

    Moderator’s note: Referenced images for this post have been received from the original author and added to the post.

    #466886
    Pam Banning
    Moderator

    Hello Hiu (and many thanks to Tim for augmenting the original post),

    Since report option 2 is using a more granular approach, with LOINC terms for each section, I would suggest saving 93193-1 for reporting option 1 solely.

    There are a series of department role review terms, one of which may apply to this Clinical Interpretation. Presuming this is not a pathologist interpretation or a medical director interpretation, which have their own LOINC terms.

    You can locate the department role review terms in search.loinc.org by entering   review  xxx  nar

    I would suggest using 69047-0 Geneticist review of results

    Thank you for considering,

    Pam

    #466890
    HIU LAAM LAM
    Participant

    Thanks Tim for adding the attachment and Thank you for the expert advice from Jami and Pam.

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