56744-6PL-7 Ab [Presence] in Serum by ImmunoblotActive
Part Description
LP30804-6 PL-7
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books:NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. [PMID:23573256] Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. [PMID:17392287] Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes.
Source: Regenstrief LOINC, PMID: 23573256
Fully-Specified Name
- Component
- Pl-7 Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IB
Additional Names
- Short Name
- PL7 Ab Ser Ql IB
- Display Name
- PL-7 Ab IB Ql (S)
- Consumer Name Alpha
- PL-7 antibody, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.29
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common US Lab Results Rank
- 13526
Member of these Groups
| LG13328-6 | Pl-7 Ab| |
Language Variants Get Info
- zh-CNChinese (China)
- Pl-7 抗体:
存在情况或阈值: 时间点: 血清: 序数型: 免疫印迹法 - nl-NLDutch (Netherlands)
- PL-7 As:
aanwezigheid: moment: serum: ordinaal: immunoblotting - et-EEEstonian (Estonia)
- PL-7 antikehad:
PrThr: Pt: S: Ord: IB - fr-BEFrench (Belgium)
- Pl-7 Ac:
PrThr: Temps ponctuel: Sérum: Ordinal: Immunoblot - fr-CAFrench (Canada)
- Pl-7 , Ac:
Présence-Seuil: Temps ponctuel: Sérum: Ordinal: Immunoblot - fr-FRFrench (France)
- PL-7 anticorps:
Présence/Seuil: Ponctuel: Sérum: Qualitatif: Immunoblot - it-ITItalian (Italy)
- PL-7 Ab:
PrThr: Pt: Siero: Ord: IB - pt-BRPortuguese (Brazil)
- Pl-7 Ac:
#N/A: Pt: Soro: Ord: Imunoblot - ru-RURussian (Russian Federation)
- PL-7 Ат:
PrThr: ТчкВрм: Сыв: Пор: ИБ - es-MXSpanish (Mexico)
- PL-7 Ab:
Presencia o umbral: Punto temporal: Suero: Ordinal: Inmunotransferencia - es-ESSpanish (Spain)
- Pl-7 Anticuerpos:
PrThr: Punto temporal: Suero: Ord: Inmunoblot (IB) - tr-TRTurkish (Turkey)
- PL-7 Ab:
MevcEşik: Zmlı: Ser: Srl: IB
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=56744-6
LOINC Copyright
Copyright © 2022 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright