Version 2.73

81714-8Centromere protein A Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP157213-2   Centromere protein A Ab
Centromere protein A, also known as Histone H3-like centromeric protein A (CENP-A), replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. It is required for recruitment and assembly of kinetochore proteins, progression of mitosis and segregation of chromosomes. [UniProt:P49450] Anti-CENP-A antibodies are a marker of systemic sclerosis (SSc), a multisystem autoimmune connective tissue disorder that is characterized by vascular abnormalities, excessive collagen synthesis, and autoantibodies to nuclear and nucleolar proteins. Approximately 20-40% of patients with SSc are positive for anti-CENP-A or-B antibodies, and these patients are at higher risk of developing pulmonary arterial hypertension, but a lower risk of early interstitial lung disease, at least early in the disease course. [PMID:26455561] Source: Regenstrief LOINC, PMID: 26455561

LP157222-3   Centromere protein A
Centromere protein A (CENP-A) is an essential centromere protein encoded by the CENPA gene. Overexpression of CENP-A causes chromosomal aberrations, and depletion of CENP-A promotes apoptosis and induces cell cycle arrest. Overexpression of CENP-A has been associated with high grade cancers and is a prognostic factor for patients with estrogen receptor (ER)-positive breast cancer. Antibodies to CENP-A are associated with scleroderma, systemic sclerosis, CREST syndrome, and other rheumatologic diseases. Source: Regenstrief LOINC

Fully-Specified Name

Centromere protein A Ab
Line blot

Additional Names

Short Name
CENP A Ab Ser Ql Line blot
Display Name
Centromere protein A Ab Line blot Ql (S)
Consumer Name Alpha
Centromere Protein A antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.56
Last Updated
Version 2.64
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
着丝粒蛋白 A 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法
nl-NLDutch (Netherlands)
centromeereiwit A As:aanwezigheid:moment:serum:ordinaal:lijnblot
fr-FRFrench (France)
Centromère protéine A anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)
Centromero, proteina A Ab:PrThr:Pt:Siero:Ord:Line blot
es-MXSpanish (Mexico)
Centrómero de proteína A Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
es-ESSpanish (Spain)
Proteína A del centrómero (CENP-A) Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot

LOINC FHIR® API Example - CodeSystem Request Get Info