Version 2.73

82472-2Borrelia garinii+afzelii oppA1 gene [Presence] in Specimen by NAA with non-probe detectionActive

Term Description

The DNA amplification target is the 283-bp plasminogen-binding protein gene (oppA1), which is present at a frequency of one copy per organism in all four pathogenic species of the Borrelia burgdorferi sensu lato genogroup (Borrelia burgdorferi sensu stricto, Borrelia afzelii, Borrelia garinii, and Borrelia mayonii). Melting curve analysis is used to differentiate B. afzelii and B. garinii from the other two species but cannot differentiate between B. afzelii and B. garinii. Potential specimens include CSF, tissue, and synovial fluid.
Source: Regenstrief LOINC

Part Descriptions

LP220480-0   Borrelia garinii+afzelii oppA1 gene
Lyme disease is a multisystem, multistage infection caused by three species of tick-borne spirochetes in the Borrelia burgdorferi sensu lato genogroup. These spirochetes include B. burgdorferi sensu stricto (North America and Western Europe), B. afzelii (Central and Western Europe and Russia), and B. garinii (Europe, Russia, and northern Asia). Endemic areas for Lyme disease in the United States correspond with the distribution of two tick species, Ixodes dammini (Northeastern and Upper Midwestern US) and Ixodes pacificus (West Coast US). In Europe, Ixodes ricinus transmits the spirochete. Human Lyme borreliosis, the most prevalent arthropod-borne infection in temperate climate zones around the world, is an inflammatory disorder characterized by the skin lesion erythema migrans and the potential development of neurologic, cardiac, and joint abnormalities. B. garinii, the most neurotropic of these three genospecies, causes most neurologic Lyme disease in Europe, including cases of meningopolyneuritis and, rarely, encephalomyelitis. Although probably all three genospecies can cause all major manifestations, it appears that infection with different B. burgdorferi sensu lato genospecies results in distinct presentations of Lyme borreliosis. In Europe, B. afzelii is mostly associated with skin manifestations, such as erythema migrans, and acrodermatitis chronica atrophicans, whereas B. garinii is the main cause of Lyme neuroborreliosis. Patients with B. garinii isolated from CSF samples have a distinct clinical presentation, compared with that of patients with B. afzelii infection. [PMID:16912943][PMID:12454161] Source: Regenstrief LOINC

LP220480-0   Borrelia garinii+afzelii oppA1 gene
The oppA1 gene is a member of a family of three genes; oppA-1, oppA-2, and oppA-3, that encode predicted peptide-binding proteins. Peptide-binding protein dependent transport systems are recognized to play important roles in microbial cell signaling and virulence. [PMID:9712756] Source: Regenstrief LOINC

Fully-Specified Name

Borrelia garinii+afzelii oppA1 gene

Additional Names

Short Name
B gar+afz oppA1 Spec Ql NAA+non-probe
Display Name
B. garinii+afzelii oppA1 gene NAA+non-probe Ql (Specimen)
Consumer Name Alpha
Borrelia garinii+afzelii oppA1 gene, Specimen

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.69
Change Reason
Release 2.68: COMPONENT: Removed parentheses from Component for consistency and accuracy.; Previous Releases:
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
加里疏螺旋体+阿夫塞疏螺旋体 oppA1 基因:存在情况或阈值:时间点:XXX:序数型:非探针法.基因扩增.靶向
fr-FRFrench (France)
Borrelia garinii+afzelii oppA1 gène:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Non-PCR amplification de cible
it-ITItalian (Italy)
Borrelia garinii+afzelii (oppA1), gene:PrThr:Pt:XXX:Ord:Non-sonda.amp.tar
es-MXSpanish (Mexico)
Borrelia garinii + gen oppA1 de afzelii:Presencia o umbral:Punto temporal:XXX:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
es-ESSpanish (Spain)
Gen oppA1 de Borrelia garinii+afzelii:PrThr:Punto temporal:XXX:Ord:Amplificación del objetivo no basado en sonda

LOINC FHIR® API Example - CodeSystem Request Get Info