Version 2.73

85366-3Neutrophil membrane IgM Ab [Presence] in Serum by ImmunofluorescenceActive

Term Description

The results of this test are determined by immunofluorescent patterns.
Source: Regenstrief LOINC

Part Description

LP232481-4   Neutrophil membrane Ab.IgM
Antineutrophil antibodies are antibodies that bind to antigens on the surface of neutrophils. The IgG Fc receptor on the neutrophil membrane surface is the primary target for antineutrophil antibodies. It was first recognized that these antibodies were a cause of autoimmune neutropenia (AIN) in 1975. Neutropenia is separated into three categories according to the risk of infection and based on the concentration of circulating neutrophils: mild neutropenia (1000-1500 cells/uL) moderate neutropenia (500-1000 cells/uL) and severe (less than 500 cells/uL). In some AIN the neutrophil numbers are normal but some functions are compromised including their ability to influence adhesion, aggregation, chemotaxis, phagocytosis and metabolic activation. AIN has two subcategories including primary AIN and secondary AIN. In primary IAN there is no association with another pathology. Primary IAN is most common in neonates and results in moderate to severe neutropenia, rarely leads to infection and is self-limiting. Secondary IAN usually occurs following a systemic autoimmune or haemitological disease including infectious diseases, solid or haematological neoplasms, neurological diseases, bone marrow or stem cell trnasplants, kidney transplants and the use of some drugs. In light of the difficulty in detecting autoimmune antineutrophil antibodies, it is recommended that both immunofluorescent and agglutination tests be performed.[PMID:16207350] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Regenstrief LOINC, IgM

Fully-Specified Name

Neutrophil membrane Ab.IgM

Additional Names

Short Name
Neutrophil membrane IgM Ser Ql IF
Display Name
Neutrophil membrane IgM IF Ql (S)
Consumer Name Alpha
Neutrophil membrane IgM antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.61
Last Updated
Version 2.61
Order vs. Observation

Language Variants Get Info

zh-CNChinese (China)
嗜中性粒细胞膜 抗体.IgM:存在情况或阈值:时间点:血清:序数型:免疫荧光法
nl-NLDutch (Netherlands)
neutrofiel membraan As.IgM:aanwezigheid:moment:serum:ordinaal:immunofluorescentie
fr-FRFrench (France)
Membrane des polynucléaires neutrophiles anticorps IgM:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunofluorescence
it-ITItalian (Italy)
Membrana neutrofili Ab.IgM:PrThr:Pt:Siero:Ord:IF
es-MXSpanish (Mexico)
IgM de membrana de neutrófilos:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunofluorescencia (IF)
es-ESSpanish (Spain)
Membrana neutrófila IgM:PrThr:Punto temporal:Suero:Ord:Inmunofluorescencia (IF)

LOINC FHIR® API Example - CodeSystem Request Get Info