Version 2.73

85827-4Carbapenem resistance bla OXA-48-like gene [Presence] by Molecular methodActive

Term Description

This test reports the presence of the OXA-48-like bacterial carbapenemase resistance type gene in gram negative bacterial isolates. This term was created for, but is not limited in use to, the submitter's modified protocol for the Check-Points Check-MDR CT103XL assay.
Source: Regenstrief LOINC

Part Description

LP248274-5   Bacterial carbapenem resistance blaOXA-48-like gene
The existence of OXA-48 like class D beta-lactamases has been increasing in enterobacter species organisms. The "OXA-like" groups of genes are molecularly similar to and thought to evolve from the original gene for which the group is named. For example, as of 2014 the blaOXA-23-like group included 19 genes, including including blaOXA-23, -27, -49, and -73. [PMID:24696435]. The OXA-48 like class D beta-lactamase enzymes are highly resistant to penicillins and beta lactamase inhibitors and show a low resistance to carbapenems. These varied OXA-48-like beta-lactamases have been identified worldwide, including OXA-48-like producing Klebsiella pneumoniae with resistance to multiple drugs that emerged in Jordanian hospitals. Reports have shown that organisms producing OXA-48 like enzymes are either not resistant to broad-spectrum cephalosporins or show a decreased susceptibility to carbapenemase drugs. Identifying them can be a challenge. Screening and detection is required to prevent and control dissemination.[PMID:22499996] [PMID:26993738] Source: Regenstrief LOINC

Fully-Specified Name

Bacterial carbapenem resistance blaOXA-48-like gene

Additional Names

Short Name
blaOXA-48-like Islt/Spm Ql
Display Name
Carbapenem resistance bla OXA-48-like gene Molgen Ql (Islt/Spec)
Consumer Name Alpha
Carbapenem resistance bla OXA-48-like gene

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.61
Last Updated
Version 2.67
Change Reason
Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation

Member of these Panels

LOINC Long Common Name
97324-8 Carbapenem resistant bacteria identification and resistance panel by Molecular genetics method
85502-3 Carbapenemase resistance genes panel by Molecular genetics method
93698-9 Gram negative bacterial resistance panel by Molecular genetics method
97608-4 Joint pathogens panel - Synovial fluid by NAA with non-probe detection
92958-8 Respiratory pathogens DNA and RNA panel - Lower respiratory specimen by NAA with non-probe detection

Language Variants Get Info

zh-CNChinese (China)
细菌碳青霉烯类耐药 blaOXA-48-样基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
nl-NLDutch (Netherlands)
bacteriële carbapenemresistentie blaOXA-48-like gen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
fr-FRFrench (France)
Résistance bactérienne aux carbapénèmases blaOXA-48-like gène:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
de-DEGerman (Germany)
Bakterielle Carbapenem-Resistenz blaOXA-48-ähnliches Gen:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
it-ITItalian (Italy)
Resistenza batterica ai carbapenemici, gene blaOXA-48-like:PrThr:Pt:Isolato/Campione:Ord:Molgen
es-MXSpanish (Mexico)
Gen de tipo blaOXA-48 de resistencia a carbapenémicos bacterianos:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
es-ESSpanish (Spain)
gen bacteriano similar blaOXA-48 resistente a carbapenem:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular

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