LOINC
Version 2.73

94699-6Glutamate decarboxylase 65 Ab [Moles/volume] in Serum by ImmunoassayActive

Part Description

LP18489-2   Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. [PMID:7532143] GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years.[PMID:11114103] GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located.[PMID:22412264] Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases.[PMID:22405456] Source: Regenstrief LOINC

Fully-Specified Name

Component
Glutamate decarboxylase 65 Ab
Property
SCnc
Time
Pt
System
Ser
Scale
Qn
Method
IA

Additional Names

Short Name
GAD65 Ab Ser IA-sCnc
Display Name
Glutamate decarboxylase 65 Ab IA (S) [Moles/Vol]
Consumer Name Alpha
Glutamate decarboxylase 65 antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Observation

Member of these Groups

LG50987-3 Glutamate decarboxylase 65 Ab|SCnc|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
谷氨酸脱羧酶-65 抗体:物质的量浓度:时间点:血清:定量型:免疫测定法
nl-NLDutch (Netherlands)
glutamaatdecarboxylase 65 As:mol/volume:moment:serum:kwantitatief:immunoassay
et-EEEstonian (Estonia)
Glutamaadi dekarboksülaasi 65 vastased antikehad:SCnc:Pt:S:Qn:IA
fr-BEFrench (Belgium)
Glutamate décarboxylase 65 Ac:Concentration de substance:Temps ponctuel:Sérum:Quantitatif:IA
fr-CAFrench (Canada)
Glutamate décarboxylase 65 , Ac:Concentration de substance:Temps ponctuel:Sérum:Quantitatif:IA
fr-FRFrench (France)
Glutamate décarboxylase 65 anticorps:Moles/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
it-ITItalian (Italy)
Glutammato decarbossilasi 65 Ab:SCnc:Pt:Siero:Qn:IA
ru-RURussian (Russian Federation)
Глутаматдекарбоксилаза 65 Ат:МолКонц:ТчкВрм:Сыв:Колич:IA
es-MXSpanish (Mexico)
Glutamato descarboxilasa 65 Ab:Concentración de sustancias:Punto temporal:Suero:Cuantitativo:Inmunoensayo
es-ESSpanish (Spain)
Glutamato decarboxilasa 65 Anticuerpos:Concentración de sustancia:Punto temporal:Suero:Qn:IA
tr-TRTurkish (Turkey)
Glutamat dekarboksilaz 65 Ab:SubKons:Zmlı:Ser:Kant:İA

Example Units

Unit Source
nmol/L Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94699-6