Version 2.73

LP16352-4Complement C1qActive


LP16352-4   Complement C1q
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. Source: National Library of Medicine, MeSH 2006

LP16352-4   Complement C1q
The complement system is a key part of the immune system and inflammatory response. The system has three pathways: 1) the classic pathway, 2) the alternative pathway, and 3) the lectin activation pathway. Complement (C1) is composed of 3 subunits: C1q, C1r, and C1s. Complement C1q initiates the complement pathway by binding to immunoglobulins. Absent or decreased levels of Complement C1q are seen in patients with acquired angioedema, systemic lupus erythematosus (SLE), polymyositis, and other immune complex diseases. Complement tests measure either the quantity or the activity (function) of complement proteins. In some cases, complement proteins are present but not functional, in which case a functional assay is used to detect the deficiency. Source: Regenstrief Institute

Basic Part Properties

Complement C1q
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Language Variants Get Info

zh-CNChinese (China)
补体 C1q
nl-NLDutch (Netherlands)
complement C1q
et-EEEstonian (Estonia)
Komplemendi komponent C1q
fr-BEFrench (Belgium)
Complément C1q
fr-CAFrench (Canada)
Complément C1q
it-ITItalian (Italy)
Complemento C1q
ru-RURussian (Russian Federation)
Комплемент C1q
es-ESSpanish (Spain)
Complemento C1q
tr-TRTurkish (Turkey)
Kompleman C1q