Carbapenemase genes and genetic platforms in Gram-negative bacilli: Enterobacteriaceae, Pseudomonas and Acinetobacter species

Clin Microbiol Infect. 2014 Sep;20(9):831-8. doi: 10.1111/1469-0691.12655. Epub 2014 Jun 14.

Abstract

The emergence and rapid spread of carbapenemases in Enterobacteriaceae, Pseudomonas and Acinetobacter (EPA) species is becoming a major public health crisis worldwide, and is responsible for large number of hospital-acquired and nosocomial infections. In this article, we review the current knowledge on the classification, phylogeny and genetic platforms of the main carbapenemases already described in Gram-negative bacteria.

Keywords: Acinetobacter; Enterobacteriaceae; Pseudomonas; carbapenemases; multidrug-resistant bacteria.

Publication types

  • Review

MeSH terms

  • Acinetobacter / enzymology*
  • Acinetobacter / genetics*
  • Bacterial Proteins / classification
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Cluster Analysis
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / genetics*
  • Genes, Bacterial
  • Humans
  • Phylogeny
  • Pseudomonas / enzymology*
  • Pseudomonas / genetics*
  • beta-Lactamases / classification
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • beta-Lactamases
  • carbapenemase