Is Staphylococcus lugdunensis Significant in Clinical Samples?

J Clin Microbiol. 2017 Nov;55(11):3167-3174. doi: 10.1128/JCM.00846-17. Epub 2017 Aug 23.

Abstract

The implication of coagulase-negative staphylococci in human diseases is a major issue, particularly in hospital settings wherein these species often act as opportunistic pathogens. In addition, some coagulase-negative staphylococci such as S. lugdunensis have emerged as pathogenic bacteria, implicated in severe infections, particularly, osteoarticular infections, foreign-body-associated infections, bacteremia, and endocarditis. In vitro studies have shown the presence of several putative virulence factors such as adhesion factors, biofilm production, and proteolytic factors that might explain clinical manifestations. Taken together, the clinical and microbiological data might change the way clinicians and microbiologists look at S. lugdunensis in clinical samples.

Keywords: Staphylococcus lugdunensis; biofilm; endocarditis; osteoarticular infections; protease; virulence.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology*
  • Staphylococcus lugdunensis / isolation & purification*
  • Staphylococcus lugdunensis / pathogenicity
  • Virulence Factors / analysis

Substances

  • Virulence Factors