FGF19 subfamily members: FGF19 and FGF21

J Physiol Biochem. 2019 Jun;75(2):229-240. doi: 10.1007/s13105-019-00675-7. Epub 2019 Mar 29.

Abstract

Fibroblast growth factors (FGF) constitute a large family of proteins with pleiotropic effects on development, organogenesis, and metabolism. The FGF19 subclass includes growth factors circulating with the blood referred to as endocrine FGF. Representatives of the FGF19 subclass, including FGF19, FGF21, and FGF23, act via FGFR receptors. The proteins of FGF19 subfamily influence the enterohepatic circulation of bile, participate in glucose and lipid metabolism regulation, and maintenance of phosphorus and vitamin D3 homeostasis. FGF19 and FGF21 are activated under different physiological and pathological conditions.

Keywords: Bile acids; FGF19; FGF21; Klotho; Metabolism regulation.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Bile Acids and Salts / metabolism
  • Carbohydrate Metabolism
  • Cholecalciferol / metabolism
  • Diabetes Mellitus / metabolism
  • Diabetes Mellitus / physiopathology
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / metabolism*
  • Glucuronidase / metabolism
  • Humans
  • Klotho Proteins
  • Lipid Metabolism
  • Obesity / metabolism
  • Obesity / physiopathology
  • Phosphorus / metabolism
  • Receptor, Fibroblast Growth Factor, Type 1 / metabolism
  • Vascular Diseases / metabolism

Substances

  • Bile Acids and Salts
  • FGF19 protein, human
  • FGF23 protein, human
  • fibroblast growth factor 21
  • Cholecalciferol
  • Phosphorus
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • FGFR1 protein, human
  • Receptor, Fibroblast Growth Factor, Type 1
  • Glucuronidase
  • Klotho Proteins