Building an I2B2-Based Population Repository for Clinical Research

Stud Health Technol Inform. 2020 Jun 16:270:78-82. doi: 10.3233/SHTI200126.

Abstract

The present work provides a real-world case of the connection process of a hospital, 12 de Octubre University Hospital in Spain, to the TriNetX research network, transforming a compilation of disparate sources into a single harmonized repository which is automatically refreshed every day. It describes the different integration phases: terminology core datasets, specialized sources and eventually automatic refreshment. It also explains the work performed on semantic normalization of the involved clinical terminologies; as well as the resulting benefits the InSite platform services have enabled in the form of research opportunities for the hospital.

Keywords: ATC; Clinical data integration; Clinical research; I2B2; ICD; LOINC; SNOMED-CT; Secondary use of EHR; Semantic interoperability.

MeSH terms

  • Semantics*
  • Spain
  • Systematized Nomenclature of Medicine*