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Part Description

LP310321-7   APOL1 inferred genotype
The APOL1 gene encodes apolipoprotein L1, which is a component of high density lipoprotein (HDL). Two variants of APOL1, called G1 and G2, are associated with significantly increased risk for chronic kidney diseases such as HIV-associated nephropathy, focal segmental glomerulosclerosis, and end-stage kidney disease due to hypertension. Increased risk occurs in people with sub-Saharan African ancestry that have at least one copy of G1 or G2, and the highest risk is in those with two copies of any combination of G1 and G2. African-American patients have been found to have a four-fold increased lifetime risk for end-stage kidney disease. From an evolutionary standpoint, the G1 and G2 protein isoforms, but not the wild type form, protect against Trypanosoma brucei rhodesiense infection (known as African sleeping sickness), which may have led to an increased frequency of these variants in places where Trypanosoma is more prevalent. PMID: 30417125 Kidneys from donors that have homozygous or heterozygous expression of high-risk APOL1 variants (i.e., G1/G1, G1/G2, G2/G2) have a higher risk of failure compared to those from donors who have at least one copy of wild type APOL1 (G0). Donor information about APOL1 may help inform the kidney donation and selection process. PMID: 25826538 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
APOL1 inferred genotype:Prid:Pt:Plas^Donor:Nom:
Long Common Name
APOL1 inferred genotype [Identifier] in Plasma from Donor
Short Name
APOL1 inferred Gentyp Plas Donr
Display Name
APOL1 inferred genotype (P donor)
Consumer Name Alpha Get Info
APOL1 inferred genotype, Donor Blood

Part Model Get Info

  • Component
    APOL1 inferred genotype
    LP310321-7
    • Analyte
      APOL1 inferred genotype
      LP310321-7
      • Component Numerator
        APOL1 inferred genotype
        LP310321-7
        • Component Numerator Core
          APOL1 inferred
          LP310322-5
        • Component Numerator Core Suffix
          genotype
          LP29254-7
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    Plas^Donor
    LP186026-3
  • Scale
    Nom
    LP7750-5
  • Method
    NULL
     

Preferred Answer List: LL5284-6

Source: Regenstrief LOINC
AnswerCodeScoreAnswer ID
APOL1 Homozygous wild typeLA29894-5
APOL1 Heterozygous wild type/G1LA29895-2
APOL1 Heterozygous wild type/G2LA29896-0
APOL1 Homozygous G1/G1LA29898-6
APOL1 Homozygous G2/G2LA29899-4
APOL1 Heterozygous G1/G2LA29897-8

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.72 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)APOL1 odvozený genotyp:Přítomnost nebo identita:Časový bod:Plazma^Dárce:Nominální:
el-GRGreek (Greece)APOL1 συναγόμενη γονότυπος:Prid:Pt:Πλάσμα^Δότης:Nom:
Synonyms: APOL1 APOL1 συναγόμενη MOLPATH Nom Prid Pt γονότυπος Δότης Πλάσμα
es-ESSpanish (Spain)APOL1 inferido Genotipo:Presencia o identidad:Punto temporal:Plasma^donante:Nom:
Synonyms: Gen APOL1
es-MXSpanish (Mexico)Genotipo inferido APOL1:Presencia o identidad:Punto temporal:Plasma ^ Donante:Nominal:
fr-FRFrench (France)APOL1 déduit génotype:Identification:Ponctuel:Plasma^donneur:Résultat nominal:
it-ITItalian (Italy)APOL1 inferita, genotipo:Prid:Pt:Plasma^donatore:Nom:
Synonyms: Patologia molecolare Plasma Presenza o Identità Punto nel tempo (episodio)
pl-PLPolish (Poland)APOL1 wnioskowany genotyp:obecność lub identyfikacja:punkt w czasie:osocze^dawca:skala nominalna:
Synonyms: wynik kategorialny
zh-CNChinese (China)APOL1 推导 基因型:存在与否或特征标识:时间点:血浆^供体:名义型:
Synonyms: APOL1 推导型;APOL1 推断型;APOL1 推演型 供血者;捐献者;捐赠者;给予体;给体;超系统 - 供体 分子病理学;分子病理学试验 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 存在;存在与否;特征标识;身份;身份标识 属模标本;遗传型 时刻;随机;随意;瞬间

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=92636-0