100799-6
21-Deoxycortisol [Mass/volume] in Serum --1st specimen post XXX challenge
Active
Part Description
LP65144-5 21-Deoxycortisol
Plasma 21-deoxycortisol (21DF) is an excellent marker of 21-hydroxylase deficiency. Currently, it is the only marker able to detect heterozygous carriers with 21-hydroxylase deficiency after Adrenocorticotropic Hormone (ACTH) stimulation. The syndrome of congenital adrenal hyperplasia (CAH) comprises the spectrum of autosomal recessive enzymatic disorders that impair cortisol biosynthesis. The hormonal pattern and clinical manifestations result from hyperstimulation of the adrenal cortex by excessive production of ACTH, untied from the negative feedback exerted by reduced cortisol levels, and the ultimate accumulation of F precursors and androgens. These abnormalities predispose the female newborn to ambiguous genitalia (female pseudohermaphroditism) and precocious puberty that may occur in both sexes. CAH due to 21-hydroxylase deficiency (21OHD) comprises nearly 90% of all cases, with an estimated worldwide incidence of 1 in 14,000 live births. Because 21-deoxycortisol (21DF) is an 11b-hydroxylase (11bOH) derivative of 17-hydroxyprogesterone (17OHP), its serum levels are parallel and proportionally elevated in patients with 21OHD but decreased or undetectable in those with 11b-hydroxylase deficiency (11bOHD). Due to the marked buildup of 17OHP in 21OHD, this precursor steroid can proceed directly to 11-hydroxylation, producing distinct elevations of 21DF. PMID: 16551734, PMID: 10731638
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, 21-Deoxycortisol
Fully-Specified Name
- Component
- 21-Deoxycortisol^1st specimen post XXX challenge
- Property
- MCnc
- Time
- Pt
- System
- Ser
- Scale
- Qn
- Method
Additional Names
- Short Name
- 21DC sp1 p chal Ser-mCnc
- Display Name
- 21-Deoxycortisol 1st specimen post Unsp challenge (S) [Mass/Vol]
- Consumer Name Alpha Get Info
- 21-Deoxycortisol 1st specimen after challenge, Blood
Basic Attributes
- Class
- CHAL
- Type
- Laboratory
- First Released
- Version 2.73
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | 21-Deoxicortisol^1er especimen pos provocación XXX: Synonyms: Cuantitativo |
et-EE | Estonian (Estonia) | 21-deoksükortisool^1. proov pärast XXX manustamist: Synonyms: Juhuslik Kvantitatiivne Seerum |
fr-CA | French (Canada) | 21-désoxycortisol^1er échantillon post test de provocation XXX: |
fr-FR | French (France) | 21-déoxycortisol T01 après épreuve: |
fr-BE | French (Belgium) | 21-déoxycortisol^1er échantillon post test de provocation XXX: Synonyms: Echantillon.1 |
it-IT | Italian (Italy) | 21-Deossicortisolo^1° campione post XXX provocazione: Synonyms: 1° campione dopo XXX stimolo Concentrazione di Massa dopo XXX provocazione Punto nel tempo (episodio) Siero Stimolo Test di provocazione |
nl-NL | Dutch (Netherlands) | 21-deoxycortisol^1ste monster na XXX belasting: |
ru-RU | Russian (Russian Federation) | 21-Дезоксикортизол^1-й образец после XXX пробы: Synonyms: Количественный Массовая концентрация первая проба; |
tr-TR | Turkish (Turkey) | 21-Deoksikortizol^1ci örnek sonr XXX girişimi: |
zh-CN | Chinese (China) | 21-脱氧皮质醇^在XXX刺激之后的第1个标本: Synonyms: 21DC; |
Example Units
Unit | Source |
---|---|
ng/mL | Example UCUM Units |
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