Version 2.78

Part Description

LP65144-5   21-Deoxycortisol
Plasma 21-deoxycortisol (21DF) is an excellent marker of 21-hydroxylase deficiency. Currently, it is the only marker able to detect heterozygous carriers with 21-hydroxylase deficiency after Adrenocorticotropic Hormone (ACTH) stimulation. The syndrome of congenital adrenal hyperplasia (CAH) comprises the spectrum of autosomal recessive enzymatic disorders that impair cortisol biosynthesis. The hormonal pattern and clinical manifestations result from hyperstimulation of the adrenal cortex by excessive production of ACTH, untied from the negative feedback exerted by reduced cortisol levels, and the ultimate accumulation of F precursors and androgens. These abnormalities predispose the female newborn to ambiguous genitalia (female pseudohermaphroditism) and precocious puberty that may occur in both sexes. CAH due to 21-hydroxylase deficiency (21OHD) comprises nearly 90% of all cases, with an estimated worldwide incidence of 1 in 14,000 live births. Because 21-deoxycortisol (21DF) is an 11b-hydroxylase (11bOH) derivative of 17-hydroxyprogesterone (17OHP), its serum levels are parallel and proportionally elevated in patients with 21OHD but decreased or undetectable in those with 11b-hydroxylase deficiency (11bOHD). Due to the marked buildup of 17OHP in 21OHD, this precursor steroid can proceed directly to 11-hydroxylation, producing distinct elevations of 21DF. PMID: 16551734, PMID: 10731638 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, 21-Deoxycortisol

Fully-Specified Name

Component
21-Deoxycortisol^2nd specimen post XXX challenge
Property
MCnc
Time
Pt
System
Ser
Scale
Qn
Method

Additional Names

Short Name
21DC sp2 p chal Ser-mCnc
Display Name
21-Deoxycortisol 2nd specimen post Unsp challenge (S) [Mass/Vol]
Consumer Name Alpha Get Info
21-Deoxycortisol 2nd specimen after challenge, Blood

Basic Attributes

Class
CHAL
Type
Laboratory
First Released
Version 2.73
Last Updated
Version 2.73
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) 21-Deoxicortisol^2º especimen pos provocación XXX:Concentración de masa:Punto temporal:Suero:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) 21-deoksükortisool^2. proov pärast XXX manustamist:MCnc:Pt:S:Qn:
Synonyms: Juhuslik Kvantitatiivne Seerum
fr-CA French (Canada) 21-désoxycortisol^2e échantillon post test de provocation XXX:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:
fr-FR French (France) 21-déoxycortisol T02 après épreuve:Masse/Volume:Ponctuel:Sérum:Numérique:
fr-BE French (Belgium) 21-déoxycortisol^2e échantillon post test de provocation XXX:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:
Synonyms: Echantillon. 2
it-IT Italian (Italy) 21-Deossicortisolo^2° campione post XXX provocazione:MCnc:Pt:Siero:Qn:
Synonyms: 2° campione dopo XXX stimolo Concentrazione di Massa dopo XXX provocazione Punto nel tempo (episodio) Siero Stimolo Test di provocazione
nl-NL Dutch (Netherlands) 21-deoxycortisol^2de monster na XXX belasting:massa/volume:moment:serum:kwantitatief:
ru-RU Russian (Russian Federation) 21-Дезоксикортизол^2-й образец после XXX пробы:МассКонц:ТчкВрм:Сыв:Колич:
Synonyms: вторая проба;порция;образец;материал для анализа Количественный Массовая концентрация Провокационная проба Сыворотка Точка во времени;Момент
tr-TR Turkish (Turkey) 21-Deoksikortizol^2ci örnek snr XXX girişimi:KütlKons:Zmlı:Ser:Kant:
zh-CN Chinese (China) 21-脱氧皮质醇^在XXX刺激之后的第2个标本:质量浓度:时间点:血清:定量型:
Synonyms: 21DC;21-脱氧可的索;21-脱氧氢化可的松;21-脱氧皮质甾醇;21-脱氧考的索 XXX刺激 - 在...之后 XXX刺激因素 之后于 XXX 刺激;之后于 XXX 刺激因素;之后于此处不作说明的刺激;之后于此处不作说明的刺激因素;在 XXX 刺激因素之后;在此处不作说明的刺激之后;在此处不作说明的刺激因素之后 之后于... 免疫之后 免疫之后的标本 免疫后 免疫后标本 刺激因素;挑战 受检物 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 在...以后 在XXX刺激因素之后的第2个标本;在此处不作说明的刺激之后的第2个标本;在此处不作说明的刺激因素之后的第2个标本;第2个标本之后于XXX刺激;第2个标本之后于XXX刺激因素;第2个标本之后于此处不作说明的刺激;第2个标本之后于此处不作说明的刺激因素 在免疫之后 在后 康复期 康复期标本 恢复期 恢复期标本 时刻;随机;随意;瞬间 样品 样本 此处不作说明的刺激 此处不作说明的刺激因素 水平;浓度;质量浓度(单位体积) 第2 第2个标本（样本、样品、试样） 第二 第二个 第二个标本 试样

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=100800-2