101144-4
Ustekinumab and Ustekinumab Ab panel - Serum or Plasma
Active
87408-1 Ustekinumab [Mass/volume] in Serum or Plasma by Immunoassay
Term Description
This term was created for, but not limited in use to, the submitter's Theradiag Lisa-Tracker Ustekinumab and anti-Ustekinumab test kits.
Part Descriptions
LP250851-5 Ustekinumab
Ustekinumab (UST) is a human immunoglobulin G1κ (IgG1κ) that binds sub-unit p40 of interleukin-12 (IL-12) and interleukin-23 (IL-23). IL-12 and IL-23 are parts of the Th1 and Th17 inflammatory pathways, respectively, and are important in the development of psoriasis. Psoriasis has pathogenic similarities to psoriatic arthritis (PsA) which is an inflammatory disorder that is often unresponsive to tumor necrosis factor (TNF) inhibitor therapy. Also, many patients with PsA who initially respond well to TNF inhibitors eventually stop responding. UST is not a TNF inhibitor and offers patients with PsA an alternative treatment which has been proven to be effective and safe for short-term use. The safety for long-term use of UST still needs further study. PMID: 24101949
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Ustekinumab
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
- IA
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.63
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 6779
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 101144-4 | Ustekinumab and Ustekinumab Ab panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Ουστεκινουμάμπη: Synonyms: MCnc Ουστεκινουμάμπη |
| es-ES | Spanish (Spain) | Ustekinumab: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Ustekinumab: |
| fr-FR | French (France) | Ustekinumab: |
| it-IT | Italian (Italy) | Ustekinumab: Synonyms: Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| nl-NL | Dutch (Netherlands) | ustekinumab: Synonyms: IA |
| zh-CN | Chinese (China) | 优特克单抗: Synonyms: 优特克单克隆抗体; |
Example Units
| Unit | Source |
|---|---|
| ug/mL | Example UCUM Units |
87409-9 Ustekinumab Ab [Units/volume] in Serum or Plasma by Immunoassay
Term Description
This term was created for, but not limited in use to, the submitter's Theradiag Lisa-Tracker Ustekinumab and anti-Ustekinumab test kits.
Part Descriptions
LP250851-5 Ustekinumab
Ustekinumab (UST) is a human immunoglobulin G1κ (IgG1κ) that binds sub-unit p40 of interleukin-12 (IL-12) and interleukin-23 (IL-23). IL-12 and IL-23 are parts of the Th1 and Th17 inflammatory pathways, respectively, and are important in the development of psoriasis. Psoriasis has pathogenic similarities to psoriatic arthritis (PsA) which is an inflammatory disorder that is often unresponsive to tumor necrosis factor (TNF) inhibitor therapy. Also, many patients with PsA who initially respond well to TNF inhibitors eventually stop responding. UST is not a TNF inhibitor and offers patients with PsA an alternative treatment which has been proven to be effective and safe for short-term use. The safety for long-term use of UST still needs further study. PMID: 24101949
Source: Regenstrief LOINC
LP250854-9 Ustekinumab Ab
Antibodies to ustekinumab (ATU) have been detected in 6.5% of patients who were receiving ustekinumab for13 months. The presence of ATU is associated with reduced levels of ustekinumab and treatment failure. The number of patients who develop ATU is similar to the number of patients who failed therapy with adalimumab regardless of whether those patients were positive or negative for antibodies to adalimumab. PMID: 26566272
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Ustekinumab Ab
- Property
- ACnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
- IA
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.63
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 6769
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 101144-4 | Ustekinumab and Ustekinumab Ab panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Ουστεκινουμάμπη Αντίσωμα: Synonyms: ACnc Ουστεκινουμάμπη |
| es-MX | Spanish (Mexico) | Ustekinumab Ab: |
| es-ES | Spanish (Spain) | Ustekinumab Anticuerpos: Synonyms: Cuantitativo |
| fr-FR | French (France) | Ustekinumab anticorps: |
| it-IT | Italian (Italy) | Ustekinumab Ab: Synonyms: anticorpo Concentrazione Arbitraria Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| nl-NL | Dutch (Netherlands) | ustekinumab As: Synonyms: antistof; |
| zh-CN | Chinese (China) | 优特克单抗 抗体: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| [arb'U]/mL | Example UCUM Units |
101145-1 Ustekinumab [Mass/volume] in Serum or Plasma by Immunoassay --trough
Part Descriptions
LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Trough levels for therapeutic drug monitoring
LP250851-5 Ustekinumab
Ustekinumab (UST) is a human immunoglobulin G1κ (IgG1κ) that binds sub-unit p40 of interleukin-12 (IL-12) and interleukin-23 (IL-23). IL-12 and IL-23 are parts of the Th1 and Th17 inflammatory pathways, respectively, and are important in the development of psoriasis. Psoriasis has pathogenic similarities to psoriatic arthritis (PsA) which is an inflammatory disorder that is often unresponsive to tumor necrosis factor (TNF) inhibitor therapy. Also, many patients with PsA who initially respond well to TNF inhibitors eventually stop responding. UST is not a TNF inhibitor and offers patients with PsA an alternative treatment which has been proven to be effective and safe for short-term use. The safety for long-term use of UST still needs further study. PMID: 24101949
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Ustekinumab^trough
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
- IA
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.74
- Last Updated
- Version 2.75 (MIN)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 101144-4 | Ustekinumab and Ustekinumab Ab panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Ουστεκινουμάμπη^ελάχιστα επίπεδα: Synonyms: MCnc |
| es-ES | Spanish (Spain) | Ustekinumab^Valle monitorización terapéutica de fármacos: Synonyms: Cuantitativo |
| fr-FR | French (France) | Ustekinumab taux résiduel: |
| it-IT | Italian (Italy) | Ustekinumab^valore minimo: Synonyms: Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM |
| nl-NL | Dutch (Netherlands) | ustekinumab^dalspiegel: Synonyms: IA |
| zh-CN | Chinese (China) | 优特克单抗^波谷: Synonyms: 一剂药物的初始剂量; |
Example Units
| Unit | Source |
|---|---|
| ug/mL | Example UCUM Units |