101145-1
Ustekinumab [Mass/volume] in Serum or Plasma by Immunoassay --trough
Active
Part Descriptions
LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety.
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Source: Wikipedia, Trough levels for therapeutic drug monitoring
LP250851-5 Ustekinumab
Ustekinumab (UST) is a human immunoglobulin G1κ (IgG1κ) that binds sub-unit p40 of interleukin-12 (IL-12) and interleukin-23 (IL-23). IL-12 and IL-23 are parts of the Th1 and Th17 inflammatory pathways, respectively, and are important in the development of psoriasis. Psoriasis has pathogenic similarities to psoriatic arthritis (PsA) which is an inflammatory disorder that is often unresponsive to tumor necrosis factor (TNF) inhibitor therapy. Also, many patients with PsA who initially respond well to TNF inhibitors eventually stop responding. UST is not a TNF inhibitor and offers patients with PsA an alternative treatment which has been proven to be effective and safe for short-term use. The safety for long-term use of UST still needs further study. PMID: 24101949
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Ustekinumab^trough
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
- IA
Additional Names
- Short Name
- Ustekinumab Trough SerPl IA-mCnc
- Display Name
- Ustekinumab trough IA [Mass/Vol]
- Consumer Name Alpha Get Info
- Ustekinumab trough, Blood
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.74
- Last Updated
- Version 2.75
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 101144-4 | Ustekinumab and Ustekinumab Ab panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Ustekinumab^Valle monitorización terapéutica de fármacos: Synonyms: Cuantitativo |
| fr-FR | French (France) | Ustekinumab taux résiduel: |
| it-IT | Italian (Italy) | Ustekinumab^valore minimo: Synonyms: Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM |
| nl-NL | Dutch (Netherlands) | ustekinumab^dalspiegel: Synonyms: IA |
| zh-CN | Chinese (China) | 优特克单抗^波谷: Synonyms: 一剂药物的初始剂量; |
Example Units
| Unit | Source |
|---|---|
| ug/mL | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=101145-1
LOINC Copyright
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