101233-5
Glutamate decarboxylase 65 Ab [Presence] in Serum by Immunoblot
Active
Part Description
LP18489-2 Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Glutamate decarboxylase 65 Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IB
Additional Names
- Short Name
- GAD65 Ab Ser Ql IB
- Display Name
- Glutamate decarboxylase 65 Ab IB Ql (S)
- Consumer Name Alpha Get Info
- Glutamate decarboxylase 65 antibody, Blood
Example Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.74
- Last Updated
- Version 2.75
- Order vs. Observation
- Both
Member of these Groups Get Info
LOINC Group | Group Name |
---|---|
LG27801-6 | Glutamate decarboxylase 65 Ab| |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Glutamato decarboxilasa 65 Anticuerpos: |
et-EE | Estonian (Estonia) | Glutamaadi dekarboksülaasi 65 vastased antikehad: Synonyms: Järgarvuline Juhuslik Seerum |
fr-BE | French (Belgium) | Glutamate décarboxylase 65 Ac: Synonyms: Anticorps |
fr-CA | French (Canada) | Glutamate décarboxylase 65, Ac: |
it-IT | Italian (Italy) | Glutammato decarbossilasi 65 Ab: Synonyms: anticorpo GAD65 Immunoblot (IB) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
nl-NL | Dutch (Netherlands) | glutamaatdecarboxylase 65 As: Synonyms: antistof; |
ru-RU | Russian (Russian Federation) | Глутаматдекарбоксилаза 65 Ат: Synonyms: Антитело Иммуноблот (ИБ) Порядковый Сыворотка Точка во времени; |
tr-TR | Turkish (Turkey) | Glutamat dekarboksilaz 65 Ab: Synonyms: Ak Mevcut |
zh-CN | Chinese (China) | 谷氨酸脱羧酶-65 抗体: Synonyms: Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright