101233-5

Glutamate decarboxylase 65 Ab [Presence] in Serum by Immunoblot

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Part Description

LP18489-2 Glutamate decarboxylase 65
Glutamate decarboxylase 65 (GAD65) antibody is useful to diagnose insulin dependent diabetes mellitus (IDDM, Type I diabetes), to assess the risk for developing IDDM, to predict the onset of IDDM and the risk of developing related endocrine disorders such as thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells and by circulating autoantibodies against a variety of islet cell antigens including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA). GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. PMID: 7532143 GAD65 antibodies are specific to patients with insulin-dependent diabetes. The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) GAD65 are also associated with paraneoplastic neurologic syndrome (PNS) which is an autoimmune disorder that is manifested by progressive neurological syndromes of any combination of the central, peripheral and autonomic nervous systems. In addition, the different PNS antibodies are associated with certain cancers and can assist in identifying where an unknown tumor is located. PMID: 22412264 Glutamic acid decarboxylase 65 antibody are associated with stiff person syndrome, cerebellar ataxia encephalitis and other neurological diseases. PMID: 22405456 Source: Regenstrief LOINC

Fully-Specified Name

Component: Glutamate decarboxylase 65 Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: IB

Additional Names

Short Name: GAD65 Ab Ser Ql IB
Display Name: Glutamate decarboxylase 65 Ab IB Ql (S)
Consumer Name Alpha Get Info: Glutamate decarboxylase 65 antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.74
Last Updated: Version 2.75
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG27801-6	Glutamate decarboxylase 65 Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Glutamato decarboxilasa 65 Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inmunoblot (IB)
et-EE	Estonian (Estonia)	Glutamaadi dekarboksülaasi 65 vastased antikehad:PrThr:Pt:S:Ord:IB Synonyms: Järgarvuline Juhuslik Seerum
fr-BE	French (Belgium)	Glutamate décarboxylase 65 Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Immunoblot Synonyms: Anticorps
fr-CA	French (Canada)	Glutamate décarboxylase 65 , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoblot
it-IT	Italian (Italy)	Glutammato decarbossilasi 65 Ab:PrThr:Pt:Siero:Ord:IB Synonyms: anticorpo GAD65 Immunoblot (IB) Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	glutamaatdecarboxylase 65 As:aanwezigheid:moment:serum:ordinaal:immunoblotting Synonyms: antistof; antilichaam IB
ru-RU	Russian (Russian Federation)	Глутаматдекарбоксилаза 65 Ат:PrThr:ТчкВрм:Сыв:Пор:ИБ Synonyms: Антитело Иммуноблот (ИБ) Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Glutamat dekarboksilaz 65 Ab:MevcEşik:Zmlı:Ser:Srl:IB Synonyms: Ak Mevcut
zh-CN	Chinese (China)	谷氨酸脱羧酶-65 抗体:存在情况或阈值:时间点:血清:序数型:免疫印迹法 Synonyms: Ab;自身抗体 GAD65;GAD-65;谷氨酸脱羧酶 65;谷氨酸脱羧酶 65（Glutamate Decarboxylase 65，GAD65，Glutamic acid decarboxylase-65，GAD-65） GADA Glu 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫印迹;西部印迹法;Immunoblot;immunoblotting;IB 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类谷氨酸脱羧酶 65 Ab 谷氨酸脱羧酶 65 抗体谷氨酸脱羧酶-65 Ab 麸胺酸去羧酶;麸胺酸去羧基酶;麸氨酸去羧基酶;GAD

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.