Version 2.78

88053-4 Cells.CD4-CD8-CD45R+TCR alpha beta+ [#/volume] in Blood by Flow cytometry (FC)

Part Descriptions

LP263674-6   Cells.CD4-CD8-CD45R+TCR alpha beta+
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder that occurs when a mutation in the FAS gene prevents the normal death cycle of the lymphocytic white blood cells. The abnormal accumulation of non-malignant lymphocytes can lead to splenomegaly, lymphadenopathy, an increased risk of malignancy, and an autoimmune cytopenia resulting in anemia and thrombocytopenia. In ALPS there is an increase in the CD4- CD8- TCR alpha beta+ T cells, FAS ligand (FAS-L), and IL-10 protein. CD4-CD8- T cells are also known as double negative T cells (DNT). The expression of an atypical isoform of CD45 called CD45R (also known as B220) on CD4-CD8-TCR alpha beta+ T cells is sensitive and specific for ALPS. PMID: 19176318 PMID: 11513545 Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD4-CD8-CD45R+TCR alpha beta+
Property
NCnc
Time
Pt
System
Bld
Scale
Qn
Method
Flow cytometry

Additional Names

Short Name
Cell.DNT-CD45R+TCRa b # Bld FC
Display Name
Cells.TCR alpha beta+DNT B220+ FC (Bld) [#/Vol]
Consumer Name Alpha Get Info
Cells.TCR Alpha Beta+DNT B220+, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
101414-1 Lymphocyte TCR alpha beta double negative subsets panel - Blood

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) Células CD4-CD8-CD45R + TCR alfa beta +:Concentración numérica:Punto temporal:Sangre:Cuantitativo:Citometría de flujo (FC)
es-ES Spanish (Spain) células.CD4-CD8-CD45R+TCR alfa beta+:Concentración de número:Punto temporal:Sangre:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
fr-FR French (France) CD4-CD8-CD45RA+TCR alpha bêta+:Nombre/Volume:Ponctuel:Sang:Numérique:Cytométrie de flux
it-IT Italian (Italy) Cellule.CD4-CD8-CD45R+TCR alpha beta+:NCnc:Pt:Sangue:Qn:Citometria a flusso
Synonyms: Cellule CD4 Cellule CD4+CD8+ Citometria a flusso (FC) Concentrazione Numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
pl-PL Polish (Poland) Komórki.CD4-CD8-CD45R+TCR alfa beta+:stężenie liczbowe:punkt w czasie:krew:ilościowy:cytometria przepływowa (FC)
Synonyms: CD4 CD8 Komórki CD4 Komórki CD4+CD8+ Komórki CD4-CD8- Komórki CD4-CD8-CD45R+TCR alfa beta+ koncentracja
zh-CN Chinese (China) 细胞.CD4-CD8-CD45R+TCR alpha beta+:计数型浓度:时间点:全血:定量型:流式细胞测量术
Synonyms: B CD4+CD8+细胞 CD4细胞 L3T4 Leu2 Leu-2 Leu3 Leu-3 T 细胞受体 A-B;T 细胞受体 alpha beta;T 细胞受体 α-β;TcR A-B;TcR α-β T4 T-4 T8 T-8 Tsuppressor W3/25 α β 动态 单位体积内的数量或计数;数量型浓度(单位体积);数量或计数型浓度(计数/体积);数量或计数型浓度(单位体积);计数型浓度(单位体积) 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抑制性 T 细胞 抑制性 T-细胞 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 细胞.CD4-CD8-CD45R+TCR αβ+;细胞.CD4-CD8-CD45R+T细胞受体αβ+;细胞.CD4-CD8-CD45R+T-细胞受体αβ+ 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 贝塔 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞 阿尔法

Example Units

Unit Source
{cells}/uL Example UCUM Units

88052-6 Cells.CD4-CD8-CD45R+TCR alpha beta+/100 CD3 cells in Blood by Flow cytometry (FC)

Part Descriptions

LP263674-6   Cells.CD4-CD8-CD45R+TCR alpha beta+
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder that occurs when a mutation in the FAS gene prevents the normal death cycle of the lymphocytic white blood cells. The abnormal accumulation of non-malignant lymphocytes can lead to splenomegaly, lymphadenopathy, an increased risk of malignancy, and an autoimmune cytopenia resulting in anemia and thrombocytopenia. In ALPS there is an increase in the CD4- CD8- TCR alpha beta+ T cells, FAS ligand (FAS-L), and IL-10 protein. CD4-CD8- T cells are also known as double negative T cells (DNT). The expression of an atypical isoform of CD45 called CD45R (also known as B220) on CD4-CD8-TCR alpha beta+ T cells is sensitive and specific for ALPS. PMID: 19176318 PMID: 11513545 Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD4-CD8-CD45R+TCR alpha beta+/100 cells.CD3
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method
Flow cytometry

Additional Names

Short Name
Cells.DNT-CD45R+TCR A-B+/100 CD3 Bld FC
Display Name
Cells.TCR alpha beta+DNT B220+/100 CD3 cells FC (Bld)
Consumer Name Alpha Get Info
Cells.TCR Alpha Beta+DNT B220+ per 100 CD3 Cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.63
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
101414-1 Lymphocyte TCR alpha beta double negative subsets panel - Blood

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) Células CD4-CD8-CD45R + TCR alfa beta + / 100 células CD3:Fracción numérica:Punto temporal:Sangre:Cuantitativo:Citometría de flujo (FC)
es-ES Spanish (Spain) células.CD4-CD8-CD45R+TCR alfa beta+/Linfocitos CD3:Fracción numérica:Punto temporal:Sangre:Qn:Citometria de flujo (FC)
Synonyms: Cuantitativo
fr-FR French (France) CD4-CD8-CD45RA+TCR alpha bêta+/100 cellules CD3+:Fraction de nombres:Ponctuel:Sang:Numérique:Cytométrie de flux
it-IT Italian (Italy) Cellule.CD4-CD8-CD45R+TCR alpha beta+/Cellule.CD3:NFr:Pt:Sangue:Qn:Citometria a flusso
Synonyms: Cellule CD3 Cellule CD4 Cellule CD4+CD8+ Citometria a flusso (FC) Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
pl-PL Polish (Poland) Komórki.CD4-CD8-CD45R+TCR alfa beta+/100 komórek CD3:frakcja liczbowa:punkt w czasie:krew:ilościowy:cytometria przepływowa (FC)
Synonyms: CD4 CD8 Komórki CD4 Komórki CD4+CD8+ Komórki CD4-CD8- Komórki CD4-CD8-CD45R+TCR alfa beta+ Komórki CD4-CD8-CD45R+TCR alfa beta+ /100 komórek CD3
zh-CN Chinese (China) 细胞.CD4-CD8-CD45R+TCR alpha beta+/100 个细胞.CD3:计数型分数:时间点:全血:定量型:流式细胞测量术
Synonyms: B CD3细胞 CD4+CD8+细胞 CD4细胞 L3T4 Leu2 Leu-2 Leu3 Leu-3 Leu4;Leu-4;T3 T 细胞受体 A-B;T 细胞受体 alpha beta;T 细胞受体 α-β;TcR A-B;TcR α-β T4 T-4 T8 T-8 Tsuppressor W3/25 α β 动态 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抑制性 T 细胞 抑制性 T-细胞 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 细胞.CD4-CD8-CD45R+TCR αβ+;细胞.CD4-CD8-CD45R+T细胞受体αβ+;细胞.CD4-CD8-CD45R+T-细胞受体αβ+ 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 贝塔 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞 阿尔法

Example Units

Unit Source
% Example UCUM Units

80699-2 CD4-CD8-/100 CD3+TCR alpha beta+ cells in Blood

Part Descriptions

LP200632-0   Cells.CD4-CD8-
T-cell receptors (TCR) are composed of two polypeptide chains. The majority of TCRs have an alpha and a beta chain, but some have a gamma and delta chain. Most T cells that express TCR alpha beta are either CD4+ or CD8+. However, double-negative T cells, which are both CD4- and CD8-, also express TCR alpha beta. Double-negative T cells are associated with and may play a role in the pathogenesis of certain autoimmune and inflammatory conditions, including systemic lupus erythematosus (SLE) and autoimmune lymphoproliferative syndrome. PMID: 25825451 Source: Regenstrief LOINC, PMID: 25825451

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD4-CD8-/100 Cells.CD3+TCR alpha beta+
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Short Name
CD4-CD8-/100 CD3+TCR A-B+ NFr Bld
Display Name
CD4-CD8-/100 CD3+TCR alpha beta+ cells (Bld)
Consumer Name Alpha Get Info
CD4-CD8- per 100 CD3+TCR Alpha Beta+ Cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.56
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
101414-1 Lymphocyte TCR alpha beta double negative subsets panel - Blood

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Células CD4-CD8-/Linfocitos CD3+TCR alpha beta+:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cells.CD4-CD8- / 100 Cells.CD3 + TCR alpha beta +:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) CD4-CD8-/100 cellules CD3+TCR alpha bêta+:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Cellule.CD4-CD8-/Cellule.CD3+TCR alpha beta+:NFr:Pt:Sangue:Qn:
Synonyms: Cellule CD3 Cellule CD3+TCR Cellule CD3+TCR alfa beta+ Cellule CD4 Cellule CD4+CD8+ Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) cellen.CD4-CD8-/100 cellen.CD3+TCR alfa beta+:getalsfractie:moment:bloed:kwantitatief:
pl-PL Polish (Poland) Komórki.CD4-CD8-/100 komórek CD3+ TCR alfa beta+:frakcja liczbowa:punkt w czasie:krew:ilościowy:
Synonyms: CD4 CD8 Komórki CD4 Komórki CD4+CD8+ Komórki CD4+CD8+/100 komórek Komórki CD4-CD8- Komórki CD4-CD8-/100 komórek CD3+TCR alfa beta+
zh-CN Chinese (China) 细胞.CD4-CD8-/100 个细胞.CD3+TCR alpha beta+:计数型分数:时间点:全血:定量型:
Synonyms: 100 个细胞.CD3+TCR αβ+ B CD3+TcR细胞;CD3+细胞受体细胞;细胞.CD3+T细胞受体 CD3+T细胞受体 Alpha Beta+细胞;CD3+T细胞受体 αβ+细胞;CD3+TcR Alpha Beta+细胞;CD3+TcR αβ+细胞;细胞.CD3+T细胞受体 alpha beta+;细胞.CD3+TcR αβ+ CD3细胞 CD4+CD8+细胞 CD4细胞 L3T4 Leu2 Leu-2 Leu3 Leu-3 Leu4;Leu-4;T3 T 细胞受体 A-B;T 细胞受体 alpha beta;T 细胞受体 α-β;TcR A-B;TcR α-β T4 T-4 T8 T-8 Tsuppressor W3/25 α β 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抑制性 T 细胞 抑制性 T-细胞 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 贝塔 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞 阿尔法

Example Units

Unit Source
% Example UCUM Units