101649-2

Tau protein [Mass/volume] in Cerebral spinal fluid by Immunoassay

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Part Descriptions

LP28537-6   Tau protein
CSF tau phosphorylated at threonine 181 (p-tau181) is a widely used biomarker for Alzheimer disease (AD) and has recently been regarded to reflect β-amyloid and/or p-tau deposition in the AD brain. Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by intranuclear inclusions in neurons, glial cells, and other somatic cells. Symptoms include dementia, neuropathy, and others. CSF biomarkers were not reported. The objective of this study was to investigate whether CSF biomarkers including p-tau181 are altered in patients with NIID. Source: Máxima MC,

LP28537-6   Tau protein
Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.

Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability: isoforms and phosphorylation.

Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2,3, and 10 of the tau gene.

Phosphorylation of tau is regulated by a host of kinases. For example, PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization Taniguchi et al., 2001. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Tau protein

Fully-Specified Name

Component

Tau protein

Property

MCnc

Time

Pt

System

CSF

Scale

Qn

Method

IA

Additional Names

Short Name

Tau Prot CSF IA-mCnc

Display Name

Tau protein IA (CSF) [Mass/Vol]

Consumer Name Alpha Get Info

Tau protein, Spinal fluid

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.75

Last Updated

Version 2.75

Order vs. Observation

Both

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Alzheimer disease
• Alzheimer's disease
• Cerebral spinal fluid
• Cerebrospinal Fl
• Chemistry
• EIA
• ELFA
• ELISA
• Enzyme immunoassay
• IAA
• Level
• Mass concentration
• MEIA
• Point in time
• PR
• Prot
• QNT
• Quan
• Quant
• Quantitative
• Random
• Spinal Fl
• Spinal Fld
• Spinal Flu
• Spinal Fluid
• SUDS

Example Units

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CodeSystem lookup

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.