Version 2.78

Part Descriptions

LP28537-6   Tau protein
CSF tau phosphorylated at threonine 181 (p-tau181) is a widely used biomarker for Alzheimer disease (AD) and has recently been regarded to reflect β-amyloid and/or p-tau deposition in the AD brain. Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease characterized by intranuclear inclusions in neurons, glial cells, and other somatic cells. Symptoms include dementia, neuropathy, and others. CSF biomarkers were not reported. The objective of this study was to investigate whether CSF biomarkers including p-tau181 are altered in patients with NIID. Source: Máxima MC,

LP28537-6   Tau protein
Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease.

Tau proteins interact with tubulin to stabilize microtubules and promote tubulin assembly into microtubules. Tau has two ways of controlling microtubule stability: isoforms and phosphorylation.

Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2,3, and 10 of the tau gene.

Phosphorylation of tau is regulated by a host of kinases. For example, PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization Taniguchi et al., 2001. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Tau protein

Fully-Specified Name

Component
Tau protein/Tau protein.phosphorilated 181
Property
MRto
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Short Name
Tau Prot/p-tau181 MRto CSF
Display Name
Tau protein/Tau protein.phosphorilated 181 (CSF) [Mass ratio]
Consumer Name Alpha Get Info
Tau protein/Tau protein.phosphorilated 181, Spinal fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
fr-FR French (France) Protéine Tau/ Protéine Tau phosphorylée 181:Masse ratio:Ponctuel:Liquide céphalorachidien:Numérique:
it-IT Italian (Italy) Tau, proteina/Proteina Tau.fosforilata 181:MRto:Pt:LCS:Qn:
Synonyms: Chimica Liquido cerebrospinale Proteina Tau Punto nel tempo (episodio) Rapporto di Massa
nl-NL Dutch (Netherlands) tau-proteïne/tau-proteïne.gefosforyleerd 181:massaverhouding:moment:liquor cerebrospinalis:kwantitatief:
zh-CN Chinese (China) Tau 蛋白/Tau 蛋白.磷酸化 181:质量比率:时间点:脑脊液:定量型:
Synonyms: Alzheimer 病;蛋白 Tau;阿尔茨海默病 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 来自于同一体系的两种分析物的质量之比;质量比 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101752-4