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Part Description

LP40154-4   Voltage-gated calcium channel PQ type binding Ab
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder that is characterised by muscle weakness of the limbs. It is the result of an autoimmune reaction, where antibodies are formed against presynaptic voltage-gated calcium channels in the neuromuscular junction (the connection between nerves and the muscle that they supply). Around 60% of those with LEMS have an underlying malignancy, most commonly small cell lung cancer; it is therefore regarded as a paraneoplastic syndrome (a condition that arises as a result of cancer elsewhere in the body).

In LEMS, antibodies against voltage-gated calcium channels (VGCC), particularly the P/Q-type VGCC, decrease the amount of calcium that can enter the nerve ending, hence less acetylcholine can be mobilized to the neuromuscular junction. Apart from skeletal muscle, the autonomic nervous system also requires acetylcholine neurotransmission; this explains the occurrence of autonomic symptoms in LEMS. P/Q voltage-gated calcium channels are also found in the cerebellum, explaining why some experience problems with coordination. The antibodies bind particularly to the part of the receptor known as the "domain III S5-S6 linker peptide". Antibodies may also bind other VGCCs. Some have antibodies that bind synaptotagmin, a protein involved in calcium-regulated vesicle transport, rather than against VGCC. Many people with LEMS, both with and without VGCC antibodies, have detectable antibodies against the M1 subtype of the acetylcholine receptor; it is thought that their presence participates in a lack of compensation for the slow calcium influx. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Voltage-gated calcium channel PQ type binding Ab:MCnc:Pt:Ser:Qn:IA
Long Common Name
Voltage-gated calcium channel P/Q type binding Ab [Mass/volume] in Serum by Immunoassay
Short Name
VGCC-P/Q Bind Ab Ser IA-mCnc
Display Name
Voltage-gated calcium channel P/Q type binding Ab IA (S) [Mass/Vol]
Consumer Name Alpha Get Info
Voltage-gated calcium channel p/Q type binding antibody, Blood

Part Model Get Info

  • Component
    Voltage-gated calcium channel PQ type binding Ab
    LP40154-4
    • Analyte
      Voltage-gated calcium channel PQ type binding Ab
      LP40154-4
      • Component Numerator
        Voltage-gated calcium channel PQ type binding Ab
        LP40154-4
        • Component Numerator Core
          Voltage-gated calcium channel PQ type binding
          LP31738-5
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    IA
    LP217197-5

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75 (ADD)
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG51471-7Voltage-gated calcium channel PQ type binding Ab|Pt|Ser|IA

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Kanál napěťově řízený vápníkový typu P/Q vázající Ab:Hmotnostní koncentrace:Časový bod:Sérum:Kvantitativní:Imunoanalýza
el-GRGreek (Greece)Τασεο-ελεγχόμενος δίαυλος ασβεστίου Δέσμευση τύπου PQ Αντίσωμα:MCnc:Pt:Ορός:Qn:IA
Synonyms: IA MCnc Pt Qn SERO Type Αντίσωμα Ασβέστιο Ορός Τασεο-ελεγχόμενος δίαυλος ασβεστίου Τασεο-ελεγχόμενος δίαυλος ασβεστίου Δέσμευση τύπου PQ
es-ESSpanish (Spain)Canales de calcio dependientes de voltaje tipo PQ Anticuerpos:Concentración de masa:Punto temporal:Suero:Qn:IA
Synonyms: Cuantitativo
fr-BEFrench (Belgium)Fixation canal calcique type PQ voltage-dépendant Ac:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:IA
Synonyms: Anticorps
fr-FRFrench (France)Canaux calciques voltage dépendants type PQ Ac:Masse/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
fr-CAFrench (Canada)Fixation canal calcique type PQ voltage-dépendant, Ac:Concentration de masse:Temps ponctuel:Sérum:Quantitatif:IA
it-ITItalian (Italy)Canale del calcio voltaggio-dipendente di tipo PQ, legante Ab:MCnc:Pt:Siero:Qn:IA
Synonyms: anticorpo Concentrazione di Massa Immunoassay legante il canale del calcio voltaggio-dipendente Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)voltage-gated calciumkanaal PQ type binding As:massa/volume:moment:serum:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA soort
ru-RURussian (Russian Federation)Потенциал-зависимый кальциевый канал PQ тип связывающий Ат:МассКонц:ТчкВрм:Сыв:Колич:IA
Synonyms: Антитело Количественный Массовая концентрация Сыворотка Точка во времени;Момент
tr-TRTurkish (Turkey)Volta kapılı kalsiyum channel PQ tip bağlayıcı Ab:KütlKons:Zmlı:Ser:Kant:İA
Synonyms: Ak İmmünölçüm, immünoassay
zh-CNChinese (China)PQ 型电压门控钙离子通道结合 抗体:质量浓度:时间点:血清:定量型:免疫测定法
Synonyms: Ab;自身抗体 CA;Cal PQ 型电压门控钙离子通道结合 Ab 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 型 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 电压依赖性钙离子通道;电压门控式钙离子通道;电压门控式钙通道;电压门控性钙离子通道;电压门控性钙通道;电压门控钙通道 电压门控钙离子通道 PQ 型结合 电压门控钙离子通道 PQ 型结合 Ab 电压门控钙离子通道 PQ 型结合抗体 结合性 结合性的 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

UnitSource
g/dLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101976-9