10498-4

Keratin Ag [Presence] in Tissue by Immune stain

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Part Descriptions

LP14679-2   Keratin
A class of fibrous proteins or scleroproteins important both as structural proteins and as keys to the study of protein conformation. The family represents the principal constituent of epidermis, hair, nails, horny tissues, and the organic matrix of tooth enamel. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms an alpha-helix, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. Source: National Library of Medicine, MeSH 2006

LP14679-2   Keratin
Keratin refers to a family of fibrous structural proteins. Keratin is the key of structural material making up the outer layer of human skin. It is also the key structural component of hair and nails.

Some infectious fungi, such as those that cause athlete's foot and ringworm (i.e. the dermatophytes), or Batrachochytrium dendrobatidis (Chytrid fungus), feed on keratin.

Diseases caused by mutations in the keratin genes include Epidermolysis bullosa simplex, Ichthyosis bullosa of Siemens, Epidermolytic hyperkeratosis, Steatocystoma multiplex, Keratosis pharyngis, Rhabdoid cell formation in Large cell lung carcinoma with rhabdoid phenotype.

Furthermore, keratin expression is helpful in determining epithelial origin in anaplastic cancers. Tumors that express keratin include carcinomas, thymomas, sarcomas and trophoblastic neoplasms. Furthermore, the precise expression pattern of keratin subtypes allows prediction of the origin of the primary tumor when assessing metastases. For example, hepatocellular carcinomas typically expresse K8 and K18, and cholangiocarcinomas express K7, K8 and K18, while metastases of colorectal carcinomas express K20, but not K7 Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component

Keratin Ag

Property

PrThr

Time

Pt

System

Tiss

Scale

Ord

Method

Immune stain

Additional Names

Short Name

Keratin Ag Tiss Ql ImStn

Display Name

Keratin Ag Immune stain Ql (Tiss)

Consumer Name Alpha Get Info

Keratin antigen, Tissue

Basic Attributes

Class

PATH

Type

Laboratory

First Released

Version 1.0i

Last Updated

Version 2.73

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

16062

Language Variants Get Info

Related Names

• Antigen
• Antigens
• IHC
• Imm
• Immunohistochemical stain
• Immunostain
• ImStn
• Imun
• Imune
• Ordinal
• PATHOLOGY
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• St
• Stains
• Stn
• Tissue
• Tissue, unspecified

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CodeSystem lookup

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.